| Deuterium oxide protects against hyperthermic cell death: evidence for role of interfacial water. | |
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MedLine Citation:
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PMID: 7454858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tissue culture cells incubated at 43 degrees C show a dramatic decrease in cell survival compared with cells incubated at lower temperatures; the effect is termed hyperthermic cell death (HCD). Replacing water in the culture medium with deuterium oxide produces a dose-dependent reduction in HCD. On the basis of this and other evidence it is concluded that the mechanism of HCD involves a hydration-dependent phase transition in membrane lipids. |
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Authors:
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D J McIver; S Schurch; R Sridhar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Physiological chemistry and physics Volume: 12 ISSN: 0031-9325 ISO Abbreviation: Physiol. Chem. Phys. Publication Date: 1980 |
Date Detail:
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Created Date: 1981-03-24 Completed Date: 1981-03-24 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0202364 Medline TA: Physiol Chem Phys Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 369-72 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Survival / drug effects* Cells, Cultured Cricetinae Deuterium* Dose-Response Relationship, Drug Hot Temperature* Membrane Lipids Phospholipids Water |
| Chemical | |
Reg. No./Substance:
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0/Membrane Lipids; 0/Phospholipids; 7732-18-5/Water; 7782-39-0/Deuterium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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