Document Detail

Deuterium equilibrium time in saliva of newborn infants.
MedLine Citation:
PMID:  19322057     Owner:  NLM     Status:  MEDLINE    
There is an increasing interest about the use of stable isotopes for body composition analysis in pediatrics. To ensure the success of total body water analysis by the deuterium dilution method, it is fundamental to determine the equilibrium time (plateau) of deuterium in the body fluid studied. OBJECTIVES: We report here the equilibration time of deuterium oxide in the saliva of newborns after oral intake of the isotope. METHODS: Twenty healthy term newborn infants, 10 males and 10 females, were analyzed. Saliva was collected from each newborn before the oral administration of a 100 mg/kg dose of deuterium oxide (baseline sample) and then at 1-hour intervals for 5 hours after administration. Deuterium enrichment of saliva was determined by isotope ratio mass spectrometry according to the recommendations of the International Atomic Energy Agency. RESULTS: The plateau time of deuterium in saliva occurred 3 hours after oral administration of the stable isotope. CONCLUSION: These data are essential for further studies on the body composition of newborn infants. To the best of our knowledge, this is the first study regarding the equilibration time of deuterium in the saliva of term newborns.
Luis Angelo Marti Traver; Francisco Eulógio Martinez; Eduardo Ferriolli; Júlio Sérgio Marchini; Jacqueline Pontes Monteiro; Karina Pfrimer; Ana Paula Michelin Sanchez; Thais de Oliveira; Carlos Ducatti; José Simon Camelo
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  48     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-26     Completed Date:  2009-07-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  471-4     Citation Subset:  IM    
Department of Pediatrics, School of Medicine of Ribeirão Preto,University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
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MeSH Terms
Body Composition
Body Water / metabolism*
Deuterium / pharmacokinetics*
Deuterium Oxide / administration & dosage,  pharmacokinetics*
Infant, Newborn / metabolism*
Saliva / metabolism*
Time Factors
Reg. No./Substance:
7782-39-0/Deuterium; 7789-20-0/Deuterium Oxide

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