Document Detail


Deubiquitinating enzymes as promising drug targets for infectious diseases.
MedLine Citation:
PMID:  23151130     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Deubiquitinating enzymes (DUBs) remove ubiquitin and ubiquitin-like modifications from proteins and they have been known to contribute to processes relevant in microbial infection, such as immune responses pathways. Numerous viral and bacterial DUBs have been identified, and activities of several host DUBs are known to be modulated during the infection process, either by a pathogen or by a host. Recently there have been attempts to take advantage of this feature and design therapeutic inhibitors of DUBs that can be used to limit the spread of infection. This review is focused on exploring the potential of DUBs in the treatment of infectious diseases.
Authors:
Bindu Nanduri; Akamol E Suvarnapunya; Malabi Venkatesan; Mariola J Edelmann
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  19     ISSN:  1873-4286     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2013  
Date Detail:
Created Date:  2013-04-25     Completed Date:  2013-10-28     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  3234-47     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Infective Agents / pharmacology*
Bacterial Proteins / metabolism
Communicable Diseases / drug therapy*,  microbiology
Drug Design
Endopeptidases / metabolism*
Humans
Molecular Targeted Therapy
Protein Processing, Post-Translational
Ubiquitin / metabolism
Ubiquitination
Viral Proteins / metabolism
Grant Support
ID/Acronym/Agency:
5P20RR016476-11/RR/NCRR NIH HHS; 8 P20 GM103476-11/GM/NIGMS NIH HHS; P20 GM103476/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Bacterial Proteins; 0/Ubiquitin; 0/Viral Proteins; EC 3.4.-/Endopeptidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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