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Detrimental effects of endogenous oestrogens on primary acute myocardial infarction among postmenopausal women.
MedLine Citation:
PMID:  23055054     Owner:  NLM     Status:  PubMed-not-MEDLINE    
OBJECTIVE: Traditionally, oestrogens were considered to be protective for the cardiovascular system for premenopausal women. Therefore, we conducted a retrospective case-control study to examine the association between endogenous oestrogens and acute myocardial infarction (AMI) risk among postmenopausal women.
METHODS: A case-control study was performed among 30 primary AMI patients and 60 control subjects. Baseline characteristics data was collected and endogenous sex hormones levels were determined using chemoluminescence and radioimmunoassay methods. Conditional logistic regression models were developed with adjustment for confounders.
RESULTS: Compared with controls, the circulating oestrone, oestradiol, androstenedione and testosterone levels were significantly higher in AMI patients (P < 0.05) while the sex hormone binding globulin (SHBG) level was lower (P < 0.05). Spearman correlation coefficients showed oestradiol was positively correlated with body mass index (BMI) and waist-to-hip ratio (WHR) in cases, but not in controls. In univariable conditional logistic regression models, oestrone, oestradiol, testosterone, WHR, BMI, diabetes and hypertension were all found to be positively associated with AMI (P < 0.05). After adjusting for these factors, oestradiol (odds ratio (OR) = 4.75; 95 % confidence interval (CI) = 1.07-21.10; P = 0.04) and WHR (OR = 6.46; 95 % CI = 1.09-38.39; P = 0.04) continued to demonstrate strong positive associations with AMI.
CONCLUSIONS: A higher level of oestradiol was potentially associated with primary AMI risk among postmenopausal women.
M Dong; F Guo; J Yang; S Liu; Z Tao; Y Fang; C Zhang; J Li; G Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation     Volume:  21     ISSN:  1568-5888     ISO Abbreviation:  Neth Heart J     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-12     Completed Date:  2013-03-14     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  101095458     Medline TA:  Neth Heart J     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  175-80     Citation Subset:  -    
Department of Cardiology, Yuhuangding Hospital, Yantai City, Shang Dong Province, 264001, People's Republic of China.
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