| Detrimental effect of fractalkine on myocardial ischemia and heart failure. | |
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MedLine Citation:
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PMID: 21840883 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims Fractalkine (FKN) is a newly identified membrane-bound chemokine, its role in myocardial ischemia and heart failure is largely unknown. We attempted to investigate the role of FKN in myocardial ischemia and ischemia or pressure overload-induced ventricular remodeling and heart failure. Methods and Results FKN-induced changes of heart failure-related genes in cultured rat cardiac cells and the effect of FKN on cultured cardiomyocyte injury during anoxia-reoxygenation were examined. The direct influence of FKN neutralization on heart failure and the potential mechanism was also investigated. In mice with failing hearts, myocardial FKN expression was correlated with the lung weight/body weight ratio, left ventricular fractional shortening, and BNP expression. In cultured rat cells, exposure to FKN increased ANP expression in cardiomyocytes, matrix metalloproteinase-9 expression in fibroblasts, and intercellular adhesion molecule-1expression in microvascular endothelial cells. FKN also promoted cardiomyocyte damage during anoxia-reoxygenation and neutralizing FKN antibody treatment improved heart failure induced by myocardial infarction or pressure overload. Neutralizing FKN or its receptor inhibited the activation of mitogen-activated protein kinases in hypoxic cardiomyocytes or ischemic myocardium. Conclusion FKN promotes myocardial injury and promotes heart failure, which is associated with the activation of mitogen-activated protein kinases. |
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Authors:
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Wanling Xuan; Yulin Liao; Baihe Chen; Qiaobing Huang; Dingli Xu; Yili Liu; Jianping Bin; Masafumi Kitakaze |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-12 |
Journal Detail:
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Title: Cardiovascular research Volume: - ISSN: 1755-3245 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Cardiology, and Organ Failure Key Laboratory of Ministry of Education, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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