| Detrended fluctuation analysis is considered to be useful as a new indicator for short-term glucose complexity. | |
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MedLine Citation:
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PMID: 20809679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study clarified whether detrended fluctuation analysis (DFA) can evaluate how to advance the loss of complexity from impaired glucose tolerance (IGT) through mild diabetes mellitus (DM) to overt DM. METHODS: Continuous glucose monitoring (CGM) was done during a 48-h interval for 59 subjects from multiple centers. Subjects were divided according to CGM data into those with impaired glucose tolerance (IGT) (n = 20), mild DM (n = 13), and overt DM (n = 26). The short-term (α1) and long-term (α2) range exponentials by DFA were compared among the three groups. RESULTS: The value of α1 within 1h was significantly lower in the IGT group than in either of the other two groups (IGT vs. mild DM vs. overt DM, 1.53 ± 0.22 vs. 1.71 ± 0.17 vs. 1.77 ± 0.13, P<0.0001), and α1 within 2h differed significantly among the three groups (1.49 ± 0.13 vs. 1.57 ± 0.10 vs. 1.72 ± 0.10, P<0.0001). The α1 within 3h was significantly higher in overt DM than in either of the other two groups but did not change between IGT and mild DM (1.44 ± 0.12 vs. 1.52 ± 0.11 vs. 1.67 ± 0.09, P<0.0001). All short-term exponents decreased gradually but significantly as the window widened in all groups (P<0.0001). The α2 over 1h was significantly higher in overt DM but was unchanged in IGT and mild DM (1.22 ± 0.11 vs. 1.27 ± 0.12 vs. 1.36 ± 0.13, P = 0.0010). The α2 over 3h did not differ among the three groups. CONCLUSIONS: Progressive loss of complexity in the glycemic profile occurred from the short-term range and spread to the long-term range concomitantly with the progression of the DM state. |
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Authors:
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Naomune Yamamoto; Yutaka Kubo; Kaya Ishizawa; Gwang Kim; Tatsumi Moriya; Toshikazu Yamanouchi; Kuniaki Otsuka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Diabetes technology & therapeutics Volume: 12 ISSN: 1557-8593 ISO Abbreviation: Diabetes Technol. Ther. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-06 Completed Date: 2011-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100889084 Medline TA: Diabetes Technol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 775-83 Citation Subset: IM |
Affiliation:
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Department of Medicine, Tokyo Women's Medical University, Tokyo, Japan. in1195@poh.osaka-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Algorithms Blood Glucose / analysis* Data Interpretation, Statistical Diabetes Mellitus / blood, diagnosis*, physiopathology Diagnosis, Differential Disease Progression Female Glucose Intolerance / blood, diagnosis*, physiopathology Humans Male Middle Aged Monitoring, Ambulatory* Severity of Illness Index Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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