Document Detail

Detoxified endotoxin vaccine (J5dLPS/OMP) protects mice against lethal respiratory challenge with Francisella tularensis SchuS4.
MedLine Citation:
PMID:  20170768     Owner:  NLM     Status:  MEDLINE    
Francisella tularensis is a category A select agent. J5dLPS/OMP is a novel vaccine construct consisting of detoxified, O-polysaccharide side chain-deficient, lipopolysaccharide non-covalently complexed with the outer membrane protein of N. meningitidis group B. Immunization elicits high-titer polyclonal antibodies specific for the highly-conserved epitopes expressed within the glycolipid core that constitutes gram-negative bacteria (e.g., F. tularensis). Mice immunized intranasally with J5dLPS/OMP exhibited protective immunity to intratracheal challenge with the live vaccine strain, as well as the highly-virulent SchuS4 strain, of F. tularensis. The efficacy of J5dLPS/OMP vaccine suggests its potential utility in immunizing the general population against several different gram-negative select agents concurrently.
Stephen H Gregory; Wilbur H Chen; Stephanie Mott; John E Palardy; Nicholas A Parejo; Sara Heninger; Christine A Anderson; Andrew W Artenstein; Steven M Opal; Alan S Cross
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-02-17
Journal Detail:
Title:  Vaccine     Volume:  28     ISSN:  1873-2518     ISO Abbreviation:  Vaccine     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-29     Completed Date:  2010-06-07     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2908-15     Citation Subset:  IM    
Copyright Information:
(c) 2010 Elsevier Ltd. All rights reserved.
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MeSH Terms
Antibodies, Bacterial / blood
Bacterial Proteins / immunology
Bacterial Vaccines / immunology*
Bronchoalveolar Lavage Fluid / immunology
Colony Count, Microbial
Endotoxins / immunology*
Francisella tularensis / immunology*
Immunoglobulin A / analysis,  blood
Immunoglobulin G / analysis,  blood
Lipopolysaccharides / immunology*
Liver / microbiology
Lung / immunology,  microbiology
Mice, Inbred BALB C
Neisseria meningitidis / immunology
Serum / immunology,  microbiology
Survival Analysis
Tularemia / prevention & control*
Grant Support
K12-RR-023250/RR/NCRR NIH HHS; R21 AI055657/AI/NIAID NIH HHS; R21 AI055657-02/AI/NIAID NIH HHS; R21AI055657/AI/NIAID NIH HHS; U54 AI057159/AI/NIAID NIH HHS; U54 AI057159/AI/NIAID NIH HHS; U54 AI057159-01/AI/NIAID NIH HHS; U54 AI057168/AI/NIAID NIH HHS; U54 AI057168/AI/NIAID NIH HHS; U54 AI057168-05S20015/AI/NIAID NIH HHS
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Proteins; 0/Bacterial Vaccines; 0/Endotoxins; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Lipopolysaccharides

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