Document Detail


Detoxication disturbances and uncoupling effects in vitro of some chlorinated guaiacols, catechols and benzoquinones.
MedLine Citation:
PMID:  7428119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of chlorinated guaiacols, catechols and benzoquinones - earlier identified in discharges from pulp and paper mills -- on oxidative phosphorylation in mitochondria and on detoxication mechanisms in microsomes have been investigated. The same biological systems have been used in testing outgoing water from a sulphite plant. Trichlorocatechol and tetrachlorocatechol and the corresponding guaiacols increase N oxygenation of N,N-dimethylaniline, while C-oxygenation decreases, indicating disturbances in microsomal detoxication. The substances tested have in general an uncoupling effect on mitochondrial oxidative phosphorylation. However, tetrachloroguaiacol seems to differ in having a specific effect on the succinate dehydrogenase part of the respiratory chain. Extracts from waste water from a sulphite plant have a considerable effect on the mitochondrial system such as to produce an increase in basal respiration and a loss of respiratory control. N- and C-oxygenation and phosphorylation have been extensively used in this and other laboratories for evaluating the toxicity of chemicals. The application on water extract described here is rapid and easily handled and thus provides a valuable complement to other water quality tests.
Authors:
P Lundberg; L Renberg; E Arrhenius; G Sundström
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemico-biological interactions     Volume:  32     ISSN:  0009-2797     ISO Abbreviation:  Chem. Biol. Interact.     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-01-29     Completed Date:  1981-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0227276     Medline TA:  Chem Biol Interact     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  281-90     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Catechols / pharmacology*
Chloranil / pharmacology
Glutamates / metabolism
Guaiacol / analogs & derivatives*,  pharmacology
Malates / metabolism
Male
Metabolic Detoxication, Drug
Microsomes, Liver / drug effects,  metabolism*
Mitochondria, Liver / drug effects,  metabolism*
Oxygen Consumption
Quinones / pharmacology*
Rats
Uncoupling Agents / pharmacology*
Water Pollutants / analysis*
Water Pollutants, Chemical / analysis*
Chemical
Reg. No./Substance:
0/Catechols; 0/Glutamates; 0/Malates; 0/Quinones; 0/Uncoupling Agents; 0/Water Pollutants; 0/Water Pollutants, Chemical; 118-75-2/Chloranil; 90-05-1/Guaiacol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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