| Deterministic separation of cancer cells from blood at 10 mL/min. | |
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MedLine Citation:
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PMID: 23112922 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Circulating tumor cells (CTCs) and circulating clusters of cancer and stromal cells have been identified in the blood of patients with malignant cancer and can be used as a diagnostic for disease severity, assess the efficacy of different treatment strategies and possibly determine the eventual location of metastatic invasions for possible treatment. There is thus a critical need to isolate, propagate and characterize viable CTCs and clusters of cancer cells with their associated stroma cells. Here, we present a microfluidic device for mL/min flow rate, continuous-flow capture of viable CTCs from blood using deterministic lateral displacement (DLD) arrays. We show here that a DLD array device can isolate CTCs from blood with capture efficiency greater than 85% CTCs at volumetric flow rates of up to 10 mL/min with no effect on cell viability. |
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Authors:
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Kevin Loutherback; Joseph D'Silva; Liyu Liu; Amy Wu; Robert H Austin; James C Sturm |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-03 |
Journal Detail:
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Title: AIP advances Volume: 2 ISSN: 2158-3226 ISO Abbreviation: AIP Adv Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-10-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101566109 Medline TA: AIP Adv Country: - |
Other Details:
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Languages: ENG Pagination: 42107 Citation Subset: - |
Affiliation:
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Princeton Institute for the Science and Technology of Materials (PRISM), Princeton Universtiy, Princeton, NJ, USA ; Department of Electrical Engineering, Princeton University, Princeton, NJ, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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