| Determining the thyroid hormones T3 and T4 in the urine: an unreliable test for hypothyroidism | |
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MedLine Citation:
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PMID: 18237046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 24-year-old woman complained of tiredness, sensitivity to cold, and feelings of depression. A diagnosis of hypothyroidism based on decreased 24 h urinary T3 and T4 excretion was made, and she was treated with levothyroxin. No blood tests were done. She was referred with the question if she had other endocrine disorders. Her periods were regular, and on physical examination no abnormalities except slight acne were found. Similarly, hypothyroidism was diagnosed by decreased thyroid hormone excretion in 24 h urine, again without blood tests, in a 68-year-old woman whose mother had a goitre, and who had already been prescribed liothyronine. She had no complaints, and physical examination was unremarkable. The thyroid gland was not palpable. Thyroid peroxidase antibodies were absent in both patients. After discontinuation of medication with thyroid hormones they both remained euthyroid. It is concluded that thyroid disease did not exist in those 2 patients. Measurement of 24 h urinary T3 and T4 excretion is not an accurate diagnostic test for hypothyroidism. |
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Authors:
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W M Wiersinga; E Fliers |
Publication Detail:
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Type: Case Reports; Comment; English Abstract; Journal Article |
Journal Detail:
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Title: Nederlands tijdschrift voor geneeskunde Volume: 151 ISSN: 0028-2162 ISO Abbreviation: Ned Tijdschr Geneeskd Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2008-02-01 Completed Date: 2008-02-29 Revised Date: 2008-09-15 |
Medline Journal Info:
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Nlm Unique ID: 0400770 Medline TA: Ned Tijdschr Geneeskd Country: Netherlands |
Other Details:
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Languages: dut Pagination: 2813-5 Citation Subset: IM |
Affiliation:
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Academisch Medisch Centrum/Universiteit van Amsterdam, afd. Inwendige Geneeskunde, onderafd. Endocrinologie en Metabolisme, Amsterdam. |
Vernacular Title:
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Bepaling van schildklierhormoon (T3 en T4) in de urine: een weinig betrouwbare test voor de diagnose 'hypothyreoïdie'. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biological Markers / urine Diagnosis, Differential Female Humans Hypothyroidism / diagnosis, drug therapy, urine* Iodide Peroxidase / immunology Sensitivity and Specificity Thyroxine / therapeutic use*, urine* Treatment Outcome Triiodothyronine / urine* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; EC 1.11.1.8/Iodide Peroxidase |
| Comments/Corrections | |
Comment On:
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Ned Tijdschr Geneeskd. 2007 Dec 22;151(51):2816-9
[PMID:
18237047
]
Ned Tijdschr Geneeskd. 2007 Dec 22;151(51):2838-40 [PMID: 18237053 ] |
Comment In:
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Ned Tijdschr Geneeskd. 2008 Jul 26;152(30):1698-9
[PMID:
18714524
]
Ned Tijdschr Geneeskd. 2008 May 31;152(22):1298; author reply 1298-9 [PMID: 18590068 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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