| Determining the source of fetal adiponectin. | |
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MedLine Citation:
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PMID: 17939592 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether maternal, placental or fetal compartment contributes to the high levels of cord blood adiponectin. STUDY DESIGN: Serum adiponectin levels were compared from 62 newborns and their mothers as well as 32 newborns at delivery and 4 days postpartum. In addition, human placental tissues were tested for the presence of adiponectin mRNA by reverse transcriptase polymerase chain reaction. RESULTS: Cord blood serum adiponectin levels were significantly higher and did not correlate with maternal adiponectin levels (32.5 +/- 7.5 vs. 11.0 +/- 3.6 microg/mL, p < 0.001). Cord blood and day 4 serum adiponectin did not differ significantly (32.6 +/- 7.6 vs. 29.5 +/- 8.4 microg/mL, p < 0.3). In addition, adiponectin mRNA was not expressed in the placenta. CONCLUSION: These findings preclude the possibility of a placental or maternal origin of cord adiponectin. Thus, the high cord adiponectin levels may be attributed to fetal tissues. |
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Authors:
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Shali Mazaki-Tovi; Hannah Kanety; Clara Pariente; Rina Hemi; Yael Efraty; Eyal Schiff; Ann Shoham; Eyal Sivan |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of reproductive medicine Volume: 52 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-10-17 Completed Date: 2007-12-18 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: United States |
Other Details:
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Languages: eng Pagination: 774-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology and Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood,
genetics,
metabolism Cesarean Section Cohort Studies Female Fetal Blood / chemistry* Fetal Development / physiology Fetus / metabolism* Humans Infant, Newborn Placenta / chemistry Pregnancy RNA, Messenger / analysis Term Birth |
| Chemical | |
Reg. No./Substance:
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0/ADIPOQ protein, human; 0/Adiponectin; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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