| Determining and optimizing the precision of quantitative measurements of perfusion from dynamic contrast enhanced MRI. | |
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MedLine Citation:
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PMID: 14579401 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To examine the sensitivity of quantitative dynamic contrast enhanced MRI (DCE-MRI) perfusion maps to errors in the various source images and to determine optimal imaging parameters for reducing this sensitivity. MATERIALS AND METHODS: A detailed analysis of the precision of a DCE-MRI protocol was performed using the "propagation of errors" technique to investigate the effect of errors in the source images on errors in K(trans). Optimal parameter values and interactions between parameters were examined. The propagation of errors analysis was validated by Monte-Carlo simulations. RESULTS: The precision of K(trans) was found to be most sensitive to artifacts in the tissue portion of the baseline images and least sensitive to noise in the arterial portion of the dynamic images. The tip-angle strongly affected the precision, with the optimum being a function of tissue T1(0). CONCLUSION: Protocol optimization requires matching the tip-angle to the anticipated T1(0) of the tissue of interest; however such optimization yields a relatively small improvement. Future developmental efforts would be most productively focused on minimizing the artifact level. |
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Authors:
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Brian M Dale; John A Jesberger; Jonathan S Lewin; Claudia M Hillenbrand; Jeffrey L Duerk |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 18 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-10-27 Completed Date: 2004-03-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 575-84 Citation Subset: IM |
Copyright Information:
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Copyright 2003 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Artifacts Contrast Media Humans Magnetic Resonance Angiography / methods* Magnetic Resonance Imaging / methods* Models, Cardiovascular Monte Carlo Method Perfusion |
| Grant Support | |
ID/Acronym/Agency:
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R01CA81431-01/CA/NCI NIH HHS; R33CA/AG88144/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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