| Determining germinal centre B cell fate. | |
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MedLine Citation:
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PMID: 22595532 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The humoral immune system generates immunological memory comprising affinity matured, long-lived memory B cells and plasma cells (PCs), which are generated primarily in germinal centres (GCs). Although many factors are essential in this process, those that specifically govern B cell fate are not fully understood. The provision of T cell help to B cells is key in GC B cell fate determination, and it has become clear recently that this help involves more than direct cell-cell interactions. Recently, the cytokine interleukin (IL)-21 has been identified as a key factor that can modulate the processes within GCs and directly influence B cell fate. In this review, we examine the roles of GC cytokines in the context of cell differentiation. |
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Authors:
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Dimitra Zotos; David M Tarlinton |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-15 |
Journal Detail:
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Title: Trends in immunology Volume: - ISSN: 1471-4981 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966032 Medline TA: Trends Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia; The Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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