Document Detail

Determining exercise-induced blood flow reserve in lower extremities using phase contrast MRI.
MedLine Citation:
PMID:  18425829     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To study the changes in limb blood flow during lower extremity exercise using phase contrast (PC) MRI in normal volunteers. MATERIALS AND METHODS: Healthy volunteers performed plantar flexion exercise (<1 W) for four minutes. Flow velocity was measured using cardiac-gated, cine PC-MRI sequences (fast gradient recalled echo [GRE]; multishot echo planar imaging [EPI]) on a 3T scanner at the level of the superficial femoral artery (SFA): 1) preexercise; 2) immediately postexercise; 3) during three minutes recovery; and 4) postrecovery. RESULTS: At rest there was a triphasic flow waveform in the SFA. During exercise it changed to a monophasic pattern with an increase in total flow; there were variable changes in vessel size and flow velocity. The waveform regained the triphasic pattern during recovery. The exercise-induced flow reserve (FR) was 167 +/- 90%. CONCLUSION: PC-MRI demonstrates that the resting triphasic flow waveform transforms into a monophasic pattern with submaximal exercise and returns to baseline with recovery. This increase in the regional blood flow allows for measurement of exercise-induced FR in the SFA.
Hosakote M Nagaraj; Amol Pednekar; Cecilia Corros; Himanshu Gupta; Steven G Lloyd
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  27     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-28     Completed Date:  2008-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1096-102     Citation Subset:  IM    
Copyright Information:
(c) 2008 Wiley-Liss, Inc.
Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama, USA.
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MeSH Terms
Blood Flow Velocity / physiology*
Exercise / physiology*
Image Processing, Computer-Assisted
Lower Extremity / blood supply*
Magnetic Resonance Imaging / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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