Document Detail


Determining the contribution of asphyxia to brain damage in the neonate.
MedLine Citation:
PMID:  15238103     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies in the research laboratory have demonstrated the complex relationship between fetal and newborn asphyxia and brain damage, a balance between the degree, duration and nature of the asphyxia and the quality of the cardiovascular compensatory response. Clinical studies would support the contention that the human fetus and newborn behave in a similar manner. An accurate diagnosis of asphyxia requires a blood gas and acid base assessment. The clinical classification of fetal asphyxia is based on a measure of metabolic acidosis to confirm that fetal asphyxia has occurred and the expression of neonatal encephalopathy and other organ system complications to express the severity of the asphyxia. The prevalence of fetal asphyxia at delivery is at term, 25 per 1000 live births of whom 15% are moderate or severe; and in the preterm, 73 per 1000 live births of whom 50% are moderate or severe. It remains to be determined how often the asphyxia recognized at delivery may have been present before the onset of labor. There is a growing body of indirect and direct evidence to support the contention that antepartum fetal asphyxia is important in the occurrence of brain damage. Although much of the brain damage observed in the newborn reflects events that occurred before delivery, newborn asphyxia and hypotension, particularly in the preterm newborn, may contribute to the brain damage accounting for deficits in surviving children.
Authors:
James A Low
Related Documents :
10099763 - Group b streptococcus infection, not birth asphyxia.
12506953 - Mycoplasma hominis scalp abscess in the newborn.
19689253 - Placental growth hormone, fetal growth and the igf axis in normal and diabetic pregnancy.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  30     ISSN:  1341-8076     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-07     Completed Date:  2004-11-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  276-86     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Queen's University, Ontario, Canada. lowj@kgh.kari.net
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Asphyxia / complications*
Asphyxia Neonatorum / complications
Cardiovascular System / embryology
Female
Fetal Diseases
Fetal Growth Retardation / complications
Humans
Hypoxia, Brain / etiology*
Infant, Newborn
Pregnancy
Recurrence

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  No significant change of plasma beta-endorphin levels of psoriasis patients after synchronous balneo...
Next Document:  Two Japanese kindreds occurring endometrial cancer meeting new clinical criteria for hereditary non-...