Document Detail

Determining the contribution of asphyxia to brain damage in the neonate.
MedLine Citation:
PMID:  15238103     Owner:  NLM     Status:  MEDLINE    
Studies in the research laboratory have demonstrated the complex relationship between fetal and newborn asphyxia and brain damage, a balance between the degree, duration and nature of the asphyxia and the quality of the cardiovascular compensatory response. Clinical studies would support the contention that the human fetus and newborn behave in a similar manner. An accurate diagnosis of asphyxia requires a blood gas and acid base assessment. The clinical classification of fetal asphyxia is based on a measure of metabolic acidosis to confirm that fetal asphyxia has occurred and the expression of neonatal encephalopathy and other organ system complications to express the severity of the asphyxia. The prevalence of fetal asphyxia at delivery is at term, 25 per 1000 live births of whom 15% are moderate or severe; and in the preterm, 73 per 1000 live births of whom 50% are moderate or severe. It remains to be determined how often the asphyxia recognized at delivery may have been present before the onset of labor. There is a growing body of indirect and direct evidence to support the contention that antepartum fetal asphyxia is important in the occurrence of brain damage. Although much of the brain damage observed in the newborn reflects events that occurred before delivery, newborn asphyxia and hypotension, particularly in the preterm newborn, may contribute to the brain damage accounting for deficits in surviving children.
James A Low
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  30     ISSN:  1341-8076     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-07     Completed Date:  2004-11-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  276-86     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Queen's University, Ontario, Canada.
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MeSH Terms
Asphyxia / complications*
Asphyxia Neonatorum / complications
Cardiovascular System / embryology
Fetal Diseases
Fetal Growth Retardation / complications
Hypoxia, Brain / etiology*
Infant, Newborn

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