| Determining when enhanced pause (Penh) is sensitive to changes in specific airway resistance. | |
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MedLine Citation:
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PMID: 21240729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Penh is a dimensionless index normally used to evaluate changes in the shape of the airflow pattern entering and leaving a whole-body flow plethysmograph as an animal breathes. The index is sensitive to changes in the distribution of area under the waveform during exhalation and increases in a nonlinear fashion as the normalized area increases near the beginning of the curve. Enhanced pause (Penh) has been used to evaluate changes in pulmonary function and as a method to evaluate airway reactivity. However, the use of Penh to assess pulmonary function has been challenged (Bates et al., 2004; Lundblad et al., 2002; Mitzner et al., 2003; Mitzner & Tankersley, 1998; Petak et al., 2001; Sly et al., 2005). The objective of this study was to show how Penh of the thorax and plethysmograph flow patterns are related. That relationship is used to describe the conditions under which whole-body plethysmograph Penh measurements can be used to detect changes in sRaw. |
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Authors:
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David G Frazer; Jeffrey S Reynolds; Mark C Jackson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of toxicology and environmental health. Part A Volume: 74 ISSN: 1528-7394 ISO Abbreviation: J. Toxicol. Environ. Health Part A Publication Date: 2011 |
Date Detail:
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Created Date: 2011-01-17 Completed Date: 2011-02-22 Revised Date: 2011-04-20 |
Medline Journal Info:
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Nlm Unique ID: 100960995 Medline TA: J Toxicol Environ Health A Country: England |
Other Details:
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Languages: eng Pagination: 287-95 Citation Subset: IM |
Affiliation:
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Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. dgf1@cdc.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Airway Resistance*
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drug effects Algorithms Animals Bronchoconstrictor Agents / toxicity Methacholine Chloride / toxicity Models, Biological Plethysmography, Whole Body* Pulmonary Ventilation* Respiration Disorders / chemically induced, diagnosis*, physiopathology Respiratory System / drug effects, physiopathology Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Bronchoconstrictor Agents; 62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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