Document Detail


Determining fetal manganese exposure from mantle dentine of deciduous teeth.
MedLine Citation:
PMID:  22455722     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies addressing health effects of manganese (Mn) excess or deficiency during prenatal development are hampered by a lack of biomarkers that can reconstruct fetal exposure. We propose a method using the neonatal line, a histological feature in deciduous teeth, to identify regions of mantle dentine formed at different prenatal periods. Micromeasurements of Mn in these regions may be used to reconstruct exposure at specific times in fetal development. To test our hypothesis, we recruited pregnant women before 20 weeks gestation from a cohort of farmworkers exposed to Mn-containing pesticides. We collected house floor dust samples and mother's blood during the second trimester; umbilical cord blood at birth; and shed deciduous incisors when the child was ∼7 years of age. Mn levels in mantle dentine formed during the second trimester (as (55)Mn:(43)Ca area under curve) were significantly associated with floor dust Mn loading (r(spearman) = 0.40; p = 0.0005; n = 72). Furthermore, (55)Mn:(43)Ca in sampling points immediately adjacent the neonatal line were significantly associated to Mn concentrations in cord blood (r(spearman) = 0.70; p = 0.003; n = 16). Our results support that Mn levels in mantle dentine are useful in discerning perinatal Mn exposure, offering a potentially important biomarker for the study of health effects due to environmental Mn exposure.
Authors:
Manish Arora; Asa Bradman; Christine Austin; Michelle Vedar; Nina Holland; Brenda Eskenazi; Donald R Smith
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Validation Studies     Date:  2012-04-11
Journal Detail:
Title:  Environmental science & technology     Volume:  46     ISSN:  1520-5851     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-01     Completed Date:  2012-09-10     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5118-25     Citation Subset:  IM    
Copyright Information:
© 2012 American Chemical Society
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / analysis
Dentin / chemistry*
Dust / analysis
Female
Fetal Blood / chemistry
Humans
Manganese / analysis*,  blood
Maternal Exposure*
Tooth, Deciduous / chemistry*
Grant Support
ID/Acronym/Agency:
K99 ES019597/ES/NIEHS NIH HHS; K99 ES019597-01/ES/NIEHS NIH HHS; K99ES019597/ES/NIEHS NIH HHS; P01 ES009605/ES/NIEHS NIH HHS; P01 ES009605/ES/NIEHS NIH HHS; P01 ES009605-01/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Dust; 42Z2K6ZL8P/Manganese
Comments/Corrections

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