| Determination of urinary hippuric acid and o-cresol levels as biological indicators of toluene exposure in shoe-workers and glue sniffers. | |
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MedLine Citation:
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PMID: 12775497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, groups exposed to toluene either intentionally (glue sniffers) or unintentionally (shoe-workers) were compared. The groups were evaluated in terms of urinary levels of the toluene metabolites hippuric acid and o-cresol. Results were also compared with control values. Hippuric acid levels were determined by high performance liquid chromatography and o-cresol levels by gas liquid chromatography. The levels of hippuric acid and o-cresol were found to be statistically significantly higher in glue sniffers than in shoe-workers (p <0.001) or controls (p <0.001). In addition, the differences between the levels of urinary hippuric acid and o-cresol in the shoe-workers and in the controls were statistically significant (p <0.05 and p <0.001, respectively). These results suggest that extremely high levels of urinary hippuric acid and o-cresol indicate massive exposure to toluene. |
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Authors:
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Ismet Cok; Ayfer Dagdelen; Esin Gökçe |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals Volume: 8 ISSN: 1354-750X ISO Abbreviation: Biomarkers Publication Date: 2003 Mar-Apr |
Date Detail:
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Created Date: 2003-05-30 Completed Date: 2004-01-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9606000 Medline TA: Biomarkers Country: England |
Other Details:
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Languages: eng Pagination: 119-27 Citation Subset: IM |
Affiliation:
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Faculty of Pharmacy, Department of Toxicology, Gazi University, Ankara, Turkey. ismetc@gazi.edu.tr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aging / metabolism Alcohol Drinking / metabolism Biological Markers Child Chromatography, Gas Cresols / urine* Hippurates / urine* Humans Industry Male Middle Aged Occupational Exposure / analysis* Shoes Smoking / metabolism Solvents / pharmacokinetics* Substance Abuse Detection / methods Substance-Related Disorders / urine* Toluene / pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cresols; 0/Hippurates; 0/Solvents; 108-88-3/Toluene; 495-69-2/hippuric acid; 95-48-7/2-cresol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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