Document Detail

Determination of urinary hippuric acid and o-cresol levels as biological indicators of toluene exposure in shoe-workers and glue sniffers.
MedLine Citation:
PMID:  12775497     Owner:  NLM     Status:  MEDLINE    
In this study, groups exposed to toluene either intentionally (glue sniffers) or unintentionally (shoe-workers) were compared. The groups were evaluated in terms of urinary levels of the toluene metabolites hippuric acid and o-cresol. Results were also compared with control values. Hippuric acid levels were determined by high performance liquid chromatography and o-cresol levels by gas liquid chromatography. The levels of hippuric acid and o-cresol were found to be statistically significantly higher in glue sniffers than in shoe-workers (p <0.001) or controls (p <0.001). In addition, the differences between the levels of urinary hippuric acid and o-cresol in the shoe-workers and in the controls were statistically significant (p <0.05 and p <0.001, respectively). These results suggest that extremely high levels of urinary hippuric acid and o-cresol indicate massive exposure to toluene.
Ismet Cok; Ayfer Dagdelen; Esin Gökçe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  8     ISSN:  1354-750X     ISO Abbreviation:  Biomarkers     Publication Date:    2003 Mar-Apr
Date Detail:
Created Date:  2003-05-30     Completed Date:  2004-01-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  England    
Other Details:
Languages:  eng     Pagination:  119-27     Citation Subset:  IM    
Faculty of Pharmacy, Department of Toxicology, Gazi University, Ankara, Turkey.
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MeSH Terms
Aging / metabolism
Alcohol Drinking / metabolism
Biological Markers
Chromatography, Gas
Cresols / urine*
Hippurates / urine*
Middle Aged
Occupational Exposure / analysis*
Smoking / metabolism
Solvents / pharmacokinetics*
Substance Abuse Detection / methods
Substance-Related Disorders / urine*
Toluene / pharmacokinetics*
Reg. No./Substance:
0/Biological Markers; 0/Cresols; 0/Hippurates; 0/Solvents; 108-88-3/Toluene; 495-69-2/hippuric acid; 95-48-7/2-cresol

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