Document Detail

Determination of urinary 18-hydroxycortisol in the diagnosis of primary aldosteronism.
MedLine Citation:
PMID:  1560187     Owner:  NLM     Status:  MEDLINE    
Urinary excretion of 18-hydroxycortisol (18-OHF), 18-hydroxycorticosterone (18-OHB) and aldosterone 18-glucuronide (Aldo-18-glu) was measured in 10 patients with primary aldosteronism; 5 with aldosterone-producing adenoma (APA) and 5 with idiopathic hyperaldosteronism (IHA), 10 patients with essential hypertension (EHT) and 11 normotensive subjects. In EHT patients, urinary 18-OHF (172 +/- 15 micrograms/24h) and 18-OHB (3.1 +/- 0.6 micrograms/24h) values were not significantly different from 18-OHF (142 +/- 35 micrograms/24h) and 18-OHB (3.6 +/- 0.5 micrograms/24h) in the controls. Urinary 18-OHF values were significantly higher in APA (640 +/- 213 micrograms/24h) when compared with controls and EHT, whereas 18-OHB (11.3 +/- 1.5 micrograms/24h) values were only slightly elevated. Both 18-OHF and 18-OHB were significantly increased in APA compared with 18-OHF (232 +/- 56 micrograms/24h) and 18-OHB (4.6 +/- 0.3 micrograms/24h) in IHA. The two urinary steroids, especially 18-OHF proved to be a useful marker for the diagnosis of APA, confirming the previous findings. Aldo-18-glu was not significantly different between APA and IHA. In normal subjects when sodium intake was restricted to 48meq/day for four days the urinary 18-OHF was increased two fold to 383 +/- 59 micrograms/24h (p less than 0.01 vs control period) associated with comparable rise in plasma renin activity. This suggests that the biosynthesis of 18-OHF is partly under control of renin-angiotensin axis in normal subjects.
I Miyamori; Y Takeda; H Takasaki; Y Itoh; K Iki; R Takeda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  15     ISSN:  0391-4097     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-05-14     Completed Date:  1992-05-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  19-24     Citation Subset:  IM    
Second Department of Internal Medicine, Kanazawa University, Japan.
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MeSH Terms
18-Hydroxycorticosterone / urine
Adenoma / diagnosis,  metabolism,  urine
Adrenal Cortex / drug effects,  physiology
Adrenal Cortex Neoplasms / diagnosis,  metabolism,  urine
Aldosterone / metabolism
Diagnosis, Differential
Glucuronates / urine
Hydrocortisone / analogs & derivatives*,  urine
Hyperaldosteronism / diagnosis*,  urine*
Hypertension / diagnosis,  urine
Middle Aged
Sodium / pharmacology
Reg. No./Substance:
0/Glucuronates; 50-23-7/Hydrocortisone; 52-39-1/Aldosterone; 561-65-9/18-Hydroxycorticosterone; 7440-23-5/Sodium; 81705-06-8/18-hydroxycortisol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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