| Determination of total choline by liquid chromatography-electrospray ionization-tandem mass spectrometry in infant formulas. | |
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MedLine Citation:
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PMID: 22468354 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Choline is a water-soluble nutrient important for infants' brain and neural development. In infant formulas, choline is one of the important fortified nutrients. A single-laboratory validation study conducted an LC-electrospray ionization-MS/MS to determine total choline in infant formulas. Sample preparation was adopted from AOAC Official Method 999.14, and instrumental running conditions were optimized. The LOQ was 0.2 microg/100 g, which is significant for measuring total choline in infant formulas. Average recoveries for milk-, rice-, soybean-, and hydrolyzed protein-based samples ranged from 86.45 +/- 6.04% to 108.98 +/- 3.68%, with RSD less than 7%. The repeatability RSD (RSD(r)) range was 0.24-3.59% in within-day evaluation and 1.16-3.24% in day-to-day evaluation. Matrix effect was also investigated, and can be effectively eliminated by using an internal standard. Therefore, this method has high credibility, and could be used as a routine method of quality control, or for clinical studies and other research areas. |
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Authors:
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Shishan Fu; Baohua Tao; Shiyun Lai; Jingshun Zhang; Ren Yiping |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of AOAC International Volume: 95 ISSN: 1060-3271 ISO Abbreviation: J AOAC Int Publication Date: 2012 Jan-Feb |
Date Detail:
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Created Date: 2012-04-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9215446 Medline TA: J AOAC Int Country: United States |
Other Details:
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Languages: eng Pagination: 157-62 Citation Subset: IM |
Affiliation:
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Zhejiang Beingmate Technology Industry and Trade Co., Ltd, Beingmate Research Institute, 3875 Nanhuan Rd, Bingjiang, Hangzhou, China 310057. fss820312@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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