Document Detail


Determination of stability constants and acute toxicity of potential hepatotropic gadolinium complexes.
MedLine Citation:
PMID:  20369788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Due to their high specificity for the hepatobiliary system, iminodiacetic acid derivatives are known to form a class of hepatobiliary agents. In this paper we present new hepatotropic gadolinium complexes to be used as potential MRI contrast agents. Derivatives of N-(2-phenylamine-2-oxoethyl) iminodiacetic acid are introduced as ligands into such complexes. In this way, we hope to achieve a valuable diagnostic tool for investigating of pathological changes in the liver. Stability constants of complexes were determined by potentiometric titration in 0.1 mol L(-1) NaNO3 solution at 20.0 +/- 0.1 degrees C. Stability and selectivity constants were also determined for endogenous metal ions such as Cu2+, Ca2+, and Zn2+ with the use of SUPERQUAD computer program. Acute toxicity of new gadolinium complexes was assessed in mice and histopathology examinations were carried out.
Authors:
Elzbieta Mikiciuk-Olasik; Emilia Wojewoda; Ireneusz Bilichowski; Ma?gorzata Witczak; Boles?aw Karwowski; Ma?gorzata Wagrowska-Danilewicz; Olga Stasikowska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta poloniae pharmaceutica     Volume:  67     ISSN:  0001-6837     ISO Abbreviation:  Acta Pol Pharm     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-04-07     Completed Date:  2010-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985167R     Medline TA:  Acta Pol Pharm     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  119-27     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Chemistry and Drug Analysis, Medical University of L?d?, 1 Muszy?skiego St., 90-151 L?d?, Poland. elzbieta.mikiciuk-olasik@umed.lodz.pl
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MeSH Terms
Descriptor/Qualifier:
Acute Toxicity Tests
Animals
Contrast Media / chemistry*
Drug Stability
Female
Gadolinium / chemistry*,  toxicity*
Liver / drug effects*,  pathology
Magnetic Resonance Imaging
Male
Mice
Potentiometry
Chemical
Reg. No./Substance:
0/Contrast Media; 7440-54-2/Gadolinium

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