| Determination of spin compartment in arterial spin labeling MRI. | |
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MedLine Citation:
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PMID: 20740655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A major difference between arterial-spin-labeling MRI and gold-standard radiotracer blood flow methods is that the compartment localization of the labeled spins in the arterial-spin-labeling image is often ambiguous, which may affect the quantification of cerebral blood flow. In this study, we aim to probe whether the spins are located in the vascular system or tissue by using T2 of the arterial-spin-labeling signal as a marker. We combined two recently developed techniques, pseudo-continuous arterial spin labeling and T2-Relaxation-Under-Spin-Tagging, to determine the T2 of the labeled spins at multiple postlabeling delay times. Our data suggest that the labeled spins first showed the T2 of arterial blood followed by gradually approaching and stabilizing at the tissue T2. The T2 values did not decrease further toward the venous T2. By fitting the experimental data to a two-compartment model, we estimated gray matter cerebral blood flow, arterial transit time, and tissue transit time to be 74.0 ± 10.7 mL/100g/min (mean ± SD, N = 10), 938 ± 156 msec, and 1901 ± 181 msec, respectively. The arterial blood volume was calculated to be 1.18 ± 0.21 mL/100 g. A postlabeling delay time of 2 s is sufficient to allow the spins to completely enter the tissue space for gray matter but not for white matter. |
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Authors:
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Peiying Liu; Jinsoo Uh; Hanzhang Lu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 65 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-20 Completed Date: 2011-04-14 Revised Date: 2012-01-04 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 120-7 Citation Subset: IM |
Copyright Information:
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© 2010 Wiley-Liss, Inc. |
Affiliation:
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Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms Blood Flow Velocity / physiology Brain / anatomy & histology, physiology* Cerebral Arteries / anatomy & histology, physiology* Cerebrovascular Circulation / physiology* Female Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods* Magnetic Resonance Angiography / methods* Male Reproducibility of Results Sensitivity and Specificity Spin Labels* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG033106-01A2/AG/NIA NIH HHS; R01 MH084021-03/MH/NIMH NIH HHS; R01 MH084021-04/MH/NIMH NIH HHS; R01AG033106/AG/NIA NIH HHS; R01MH084021/MH/NIMH NIH HHS; R21 AG034318-01/AG/NIA NIH HHS; R21 EB007821-02/EB/NIBIB NIH HHS; R21AG034318/AG/NIA NIH HHS; R21EB007821/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Spin Labels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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