| Determination of the solution conformation of dephospho coenzyme A by nuclear-magnetic-resonance spectroscopy with lanthanide probes. A method for analysis when more than one complex species is present. | |
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MedLine Citation:
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PMID: 598379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aqueous solution conformation of the 1 : 1 complex of dephospho CoA bound to a lanthanide ion has been determined by examination of the dipolar shift and induced relaxation at pH 6.4. The experimental data are shown to arise from the presence of both 1 : 1 and 1 : 2 metal : ligand complexes and a graphical method is described to divide the experimental data into information corresponding to each of the two species. The formation constants are also derived. For the 1 : 1 complex the ribose is found in a 2E conformation with the adenine base predominantly anti. A small contribution from a syn conformation is evident. The pantoinic acid fragment of the chain is folded back towards the pyrophosphate while the remainder of the chain is extended. |
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Authors:
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G V Fazakerley; P W Linder; D G Reid |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of biochemistry / FEBS Volume: 81 ISSN: 0014-2956 ISO Abbreviation: Eur. J. Biochem. Publication Date: 1977 Dec |
Date Detail:
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Created Date: 1978-03-21 Completed Date: 1978-03-21 Revised Date: 2007-07-23 |
Medline Journal Info:
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Nlm Unique ID: 0107600 Medline TA: Eur J Biochem Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 507-14 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Coenzyme A / analogs & derivatives* Magnetic Resonance Spectroscopy / methods Mathematics Metals, Rare Earth Models, Molecular Molecular Conformation Pantetheine Praseodymium |
| Chemical | |
Reg. No./Substance:
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0/Metals, Rare Earth; 496-65-1/Pantetheine; 58-61-7/Adenosine; 7440-10-0/Praseodymium; 85-61-0/Coenzyme A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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