Document Detail

Determination of the site of zinc absorption in rat small intestine.
MedLine Citation:
PMID:  430207     Owner:  NLM     Status:  MEDLINE    
We have studied net uptake of zinc from segments of rat duodenum, jejunum, and ileum using in vivo intestinal perfusion. We have also evaluated the effect of pancreatic and bile secretions on duodenal zinc absorption. Segments of duodenum, jejunum, and ileum and duodenum with bile and pancreatic duct obstruction, 10 cm in length, were studied in six rats each. Percentage absorption of zinc as determined by atomic absorption spectrophotomety was greater from the ileum (60.1%) when compared to duodenum (19.1%) or jejunum (20.2%). Exclusion of bile and pancreatic secretions from the lumen increased zinc absorption in the duodenum (32.0%). Postperfusion mucosal zinc content comprised 29.0% of absorbed zinc from jejunum, 7.4% from ileum, 5.2% from duodenum, and 2.7% from duodenum with bile and pancreatic duct obstructed, indicating rapid transport of zinc across epithelial cells after uptake from the duodenum and ileum. Our data indicate that the ileum has the greatest capacity for zinc absorption.
D L Antonson; A J Barak; J A Vanderhoof
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  The Journal of nutrition     Volume:  109     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-06-29     Completed Date:  1979-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  142-7     Citation Subset:  IM    
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MeSH Terms
Duodenum / metabolism
Gallbladder / physiology
Ileum / metabolism
Intestinal Absorption*
Intestine, Small / metabolism*
Jejunum / metabolism
Organ Specificity
Zinc / metabolism*
Reg. No./Substance:

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