Document Detail

Determination of serum adenosine deaminase and xanthine oxidase levels in patients with crimean-congo hemorrhagic fever.
MedLine Citation:
PMID:  20668627     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Crimean-Congo hemorrhagic fever is an acute viral hemorrhagic fever with a high mortality rate. Despite increasing knowledge about hemorrhagic fever viruses, little is known about the pathogenesis of Crimean-Congo hemorrhagic fever. In this study, we measured serum adenosine deaminase and xanthine oxidase levels in Crimean-Congo hemorrhagic fever patients.
METHODS: Serum adenosine deaminase levels were measured with a sensitive colorimetric method described by Giusti and xanthine oxidase levels by the method of Worthington in 30 consecutive hospitalized patients (mean age 42.6 +/- 21.0). Laboratory tests confirmed their diagnoses of Crimean-Congo hemorrhagic fever. Thirty-five subjects (mean age 42.9 +/- 19.1) served as the control group.
RESULTS: There was a significant difference in adenosine deaminase and xanthine oxidase levels between cases and controls (p<0.05). However, neither adenosine deaminase nor xanthine oxidase levels varied with the severity of disease in the cases assessed (p>0.05).
CONCLUSION: Adenosine deaminase and xanthine oxidase levels were increased in patients with Crimean-Congo hemorrhagic fever. Elevated serum xanthine oxidase activity in patients with Crimean-Congo hemorrhagic fever may be associated with reactive oxygen species generated by the xanthine/xanthine oxidase system during inflammatory responses. In addition, elevated lipid peroxidation may contribute to cell damage and hemorrhage. The association of cell damage and hemorrhage with xanthine oxidase activity should be further investigated in large-scale studies.
V Kenan Celik; Ismail Sari; Aynur Engin; Yildiz Gürsel; Hüseyin Aydin; Sevtap Bakir
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  65     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-29     Completed Date:  2011-08-11     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  697-702     Citation Subset:  IM    
Department of Biochemistry, Cumhuriyet University, Sivas, Turkey.
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MeSH Terms
Adenosine Deaminase / blood*
Biological Markers / blood
Case-Control Studies
Chi-Square Distribution
Hemorrhagic Fever Virus, Crimean-Congo / enzymology*,  immunology
Middle Aged
Prospective Studies
Severity of Illness Index
Xanthine Oxidase / blood*
Young Adult
Reg. No./Substance:
0/Biological Markers; EC Oxidase; EC Deaminase

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