Document Detail


Determination of serum adenosine deaminase and xanthine oxidase levels in patients with crimean-congo hemorrhagic fever.
MedLine Citation:
PMID:  20668627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Crimean-Congo hemorrhagic fever is an acute viral hemorrhagic fever with a high mortality rate. Despite increasing knowledge about hemorrhagic fever viruses, little is known about the pathogenesis of Crimean-Congo hemorrhagic fever. In this study, we measured serum adenosine deaminase and xanthine oxidase levels in Crimean-Congo hemorrhagic fever patients.
METHODS: Serum adenosine deaminase levels were measured with a sensitive colorimetric method described by Giusti and xanthine oxidase levels by the method of Worthington in 30 consecutive hospitalized patients (mean age 42.6 +/- 21.0). Laboratory tests confirmed their diagnoses of Crimean-Congo hemorrhagic fever. Thirty-five subjects (mean age 42.9 +/- 19.1) served as the control group.
RESULTS: There was a significant difference in adenosine deaminase and xanthine oxidase levels between cases and controls (p<0.05). However, neither adenosine deaminase nor xanthine oxidase levels varied with the severity of disease in the cases assessed (p>0.05).
CONCLUSION: Adenosine deaminase and xanthine oxidase levels were increased in patients with Crimean-Congo hemorrhagic fever. Elevated serum xanthine oxidase activity in patients with Crimean-Congo hemorrhagic fever may be associated with reactive oxygen species generated by the xanthine/xanthine oxidase system during inflammatory responses. In addition, elevated lipid peroxidation may contribute to cell damage and hemorrhage. The association of cell damage and hemorrhage with xanthine oxidase activity should be further investigated in large-scale studies.
Authors:
V Kenan Celik; Ismail Sari; Aynur Engin; Yildiz Gürsel; Hüseyin Aydin; Sevtap Bakir
Related Documents :
25248687 - Further evidence in support of the association between venous thrombosis and atheroscle...
1377797 - Long-term follow-up of cerebral blood flow in patients with ruptured cerebral aneurysm.
25349227 - Incidence and clinical characteristics of transient st-t elevation during transseptal c...
17876227 - Endoscopic anatomy of the cerebral aqueduct.
6311457 - Serum 5'-nucleotidase: automation of a manual assay and brief observations on values in...
25085837 - The natural course of clinically isolated syndrome in pediatric patients.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  65     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-29     Completed Date:  2011-08-11     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  697-702     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Cumhuriyet University, Sivas, Turkey. vkcelik@cumhuriyet.edu.tr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenosine Deaminase / blood*
Adult
Biological Markers / blood
Case-Control Studies
Chi-Square Distribution
Colorimetry
Female
Hemorrhagic Fever Virus, Crimean-Congo / enzymology*,  immunology
Humans
Male
Middle Aged
Prospective Studies
Severity of Illness Index
Turkey
Xanthine Oxidase / blood*
Young Adult
Chemical
Reg. No./Substance:
0/Biological Markers; EC 1.17.3.2/Xanthine Oxidase; EC 3.5.4.4/Adenosine Deaminase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dental malocclusion and body posture in young subjects: a multiple regression study.
Next Document:  Glycosaminoglycan distribution in the rat uterine cervix during the estrous cycle.