Document Detail

Determination of saturation factors in 31P NMR spectra of the developing human brain.
MedLine Citation:
PMID:  8419745     Owner:  NLM     Status:  MEDLINE    
In order to assess the influence of longitudinal relaxation on previously reported variations in 31P NMR signals during brain development, we used an accelerated two-point technique to determine T1 at 2.35 Tesla in 8 min. Comparison between 10 normal neonates (age range 37-46 weeks postconception) and 10 healthy infants (age range 80-157 weeks postconception) indicated that T1 does not vary substantially during the first year of life, except in the phosphomonoester (PME) region of the spectra. T1 of total PME decreases with age which we could explain by its variable multicomponent nature: The signal from (unresolved) components at the downfield shoulder of PME (attributed mostly to phosphorylethanolamine at 6.72 ppm) with a T1 of at least 6.4 s decreases with age relative to contributions from other phosphomonoester compounds resonating predominantly at the upfield side of the peak (approximately 6.3 ppm), with T1 below 2.9 s. Because the T1 heterogeneity of PME may depend on its relative composition, quantitative 31P NMR spectroscopy may require an assessment of the influence of longitudinal relaxation on the signal amplitudes in each measurement.
R Gruetter; C Fusch; E Martin; C Boesch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  29     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-02-08     Completed Date:  1993-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7-11     Citation Subset:  IM    
University Children's Hospital, Zürich, Switzerland.
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MeSH Terms
Brain / growth & development*,  metabolism*
Gestational Age
Infant, Newborn
Magnetic Resonance Spectroscopy*
Phosphates / metabolism
Reg. No./Substance:

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