| Determination of reference values for a novel ketoamine-specific fructosamine assay for assessment of diabetic glycemic control. | |
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MedLine Citation:
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PMID: 11474831 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Intensive monitoring to improve glycemic control is essential for effective management of diabetes and reduction of long-term morbidity and pathology. Measurement of glycated serum proteins (fructosamine) allows more frequent assessment (monthly) of glycemic control than the 2- to 3-month window of the traditional glycated hemoglobin (HbA1c) assay. In response to concerns about assays designed to measure glycated serum proteins based on the nitroblue tetrazolium (NBT) methodology, a novel assay to measure glycated serum proteins has been developed based on the specific oxidation of the ketoamine bonds within the glycated proteins. METHODS: Reference range values for this new, enzymatic glycated-serum-protein assay (GlyPro; Genzyme Corporation, Cambridge, MA) are reported. RESULTS: The GlyPro reference range is lower and shows close correlation with ranges reported for the NBT assay. The 95% overall reference range was 122 to 236 mumol/L. CONCLUSIONS: GlyPro is a reliable, accurate assay and correlates well with the NBT assay for the measurement of glycated serum proteins. The assay may be useful in the short-term assessment of diabetes control, a necessary complement to long-term control as assessed by hemoglobin A1c (HbA1c) assays. |
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Authors:
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J E O'Brien; M Brookes |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetes technology & therapeutics Volume: 1 ISSN: 1520-9156 ISO Abbreviation: Diabetes Technol. Ther. Publication Date: 1999 |
Date Detail:
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Created Date: 2001-07-27 Completed Date: 2001-08-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100889084 Medline TA: Diabetes Technol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 447-55 Citation Subset: IM |
Affiliation:
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Quest Diagnostics Incorporated, Teterboro, New Jersey, USA. obrienj@questdiagnostics.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Blood Glucose / metabolism* Diabetes Mellitus / blood* Female Fructosamine / blood* Hemoglobin A, Glycosylated / analysis Humans Male Middle Aged Monitoring, Physiologic / methods Reference Standards Reference Values Regression Analysis Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 4429-04-3/Fructosamine |
| Comments/Corrections | |
Comment In:
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Diabetes Technol Ther. 1999 Winter;1(4):457-9
[PMID:
11474832
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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