| Determination of purines including 2,8-dihydroxyadenine in urine using capillary electrophoresis. | |
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MedLine Citation:
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PMID: 11100858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For the purpose of rapid drug monitoring, methods have been developed for the determination of 2,8-dihydroxyadenine, allopurinol, oxypurinol, adenine, hypoxanthine, hippuric acid and xanthine in urine with and without sodium dodecyl sulfate as additive in sodium tetraborate running buffer. No sample preparation is necessary. 6-methylmercaptopurine and etofylline have been used as the internal standards. The limit of detection is 5 microM and the range of quantification stretches from 20 to 2000 microM. The capillary electrophoresis methods are simple, fast and robust. |
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Authors:
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T Wessel; C Lanvers; S Fruend; G Hempel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of chromatography. A Volume: 894 ISSN: 0021-9673 ISO Abbreviation: J Chromatogr A Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2001-02-20 Completed Date: 2001-03-08 Revised Date: 2009-01-15 |
Medline Journal Info:
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Nlm Unique ID: 9318488 Medline TA: J Chromatogr A Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 157-64 Citation Subset: IM |
Affiliation:
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Abt Hämatologie/Onkologie, Universiäts-Kinderklinik, Münster, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenine
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analogs & derivatives*,
urine* Electrophoresis, Capillary / methods* Humans Purines / analysis* Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Purines; 30377-37-8/2,8-dihydroxyadenine; 73-24-5/Adenine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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