Document Detail


Determination of phthalic acid, mono-(2-ethylhexyl) phthalate and di-(2-ethylhexyl) phthalate in human plasma and in blood products.
MedLine Citation:
PMID:  3988859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pretreatment for the determination of phthalic acid, mono-(2-ethylhexyl) phthalate (MEHP) and di-(2-ethylhexyl) phthalate (DEHP) in human serum or plasma, and the determination of these compounds in blood products by high-performance liquid chromatography was studied. The amount of phthalic acid, MEHP and DEHP, migrated into blood products from a flexible bag, was studied. About 0.1% of DEHP in a flexible bag was found to have migrated into human platelet plasma. Most of the MEHP and phthalic acid detected in human platelet plasma was not derived from the flexible bag but was produced by enzymatic hydrolysis of the migrated DEHP. The amount of DEHP eluted into blood products from the flexible bag differed, depending upon storage time, storage temperature, etc.
Authors:
H Shintani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of chromatography     Volume:  337     ISSN:  -     ISO Abbreviation:  J. Chromatogr.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-06-11     Completed Date:  1985-06-11     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0427043     Medline TA:  J Chromatogr     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  279-90     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetonitriles / blood
Blood Platelets / analysis
Chromatography, High Pressure Liquid
Diethylhexyl Phthalate / analogs & derivatives,  blood*
Humans
Magnetic Resonance Spectroscopy
Phthalic Acids / blood*
Spectrophotometry, Ultraviolet
Ultrafiltration
Chemical
Reg. No./Substance:
0/Acetonitriles; 0/Phthalic Acids; 4376-20-9/mono-(2-ethylhexyl)phthalate; 6O7F7IX66E/phthalic acid; C42K0PH13C/Diethylhexyl Phthalate; Z072SB282N/acetonitrile

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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