| Determination of pharmacokinetic parameters in DCE MRI: Consequence of nonlinearity between contrast agent concentration and signal intensity. | |
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MedLine Citation:
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PMID: 16763473 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We sought to compare pharmacokinetic modeling of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data by assuming a linear and nonlinear relationship between signal intensity (SI) and contrast agent (CA) concentration. MATERIALS AND METHODS: Data sets were generated by computer-based simulation studies and DCE-MRI examination of 5 tumor-bearing mice using a 1.5 T MR-scanner. Two approaches were investigated: a linear and nonlinear relationship between SI and CA concentration before pharmacokinetic analysis. In a pharmacokinetic 2-compartment model, values of exchange rate constant kep and amplitude A were compared for both assumptions. RESULTS: In the linear approach, A was as much as 30% less for kep values between 1.0 and 5.0 min, whereas kep was as much as 60% greater, for kep between 0.2 and 5.0 min compared with the nonlinear one, as demonstrated in simulations and animal studies. CONCLUSIONS: Nonlinearity between SI and CA concentration has to be considered for accurate parameter calculation in DCE-MRI studies. |
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Authors:
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Melanie Heilmann; Fabian Kiessling; Marta Enderlin; Lothar R Schad |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Investigative radiology Volume: 41 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-09 Completed Date: 2006-11-14 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 536-43 Citation Subset: IM |
Affiliation:
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Department of Medical Physics in Radiology, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany. melanie.heilmann@curie.u-psud.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Animals Computer Simulation* Contrast Media / pharmacokinetics* Linear Models Magnetic Resonance Imaging / methods* Mice Models, Biological Sensitivity and Specificity Statistics as Topic Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
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