Document Detail


Determination of peptidoaminobenzophenone (2-o-chlorobenzoyl-4-chloro-N-methyl-N'-glycylglycinanilide) and its metabolites in human plasma by glass capillary gas chromatography negative ion chemical ionization mass spectrometry--1.
MedLine Citation:
PMID:  6131705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A highly sensitive and selective glass capillary gas chromatographic negative ion chemical ionization mass spectrometric assay was developed to measure peptidoaminobenzophenone(2-o-chlorobenzoyl-4-chloro-N-methyl-N'-glycylglycinanilide) and its metabolites; chlorodiazepam, chlorodesmethyldiazepam and lorazepam in human plasma. As peptidoaminobenzophenone underwent pyrolysis during gas chromatography, it was converted to a thermally stable aminoquinolone. Internal standards for these compounds were the respective deuterium labelled compounds. Calibration curves were prepared for the range of 1-100 ng ml-1. Interference by endogenous substances was negligible in the isobutane negative ion chemical ionization mode in contrast to the electron impact or positive ion chemical ionization mode. This method was used to determine the plasma levels in humans following oral administration of two 5 mg doses.
Authors:
S Hashimoto; E Sakurai; M Mizobuchi; S Takahashi; K Yamamoto; T Momose
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedical mass spectrometry     Volume:  9     ISSN:  0306-042X     ISO Abbreviation:  Biomed. Mass Spectrom.     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0430246     Medline TA:  Biomed Mass Spectrom     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  546-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anti-Anxiety Agents / blood*
Benzodiazepines*
Diazepam / analogs & derivatives*,  blood
Gas Chromatography-Mass Spectrometry / methods
Glycine / analogs & derivatives*,  blood
Humans
Lorazepam / blood*
Nordazepam / analogs & derivatives*,  blood
Chemical
Reg. No./Substance:
0/Anti-Anxiety Agents; 1088-11-5/Nordazepam; 12794-10-4/Benzodiazepines; 2894-67-9/chlordesmethyldiazepam; 2894-68-0/2-chlorodiazepam; 439-14-5/Diazepam; 56-40-6/Glycine; 59179-95-2/2-(2-chlorobenzoyl)-4-chloro-N-methyl-N'-glycylglycinanilide; 846-49-1/Lorazepam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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