| Determination of pentamidine transfer in the in vitro perfused human cotyledon with high-performance liquid chromatography. | |
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MedLine Citation:
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PMID: 2929699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pentamidine is used to treat Pneumocystis carinii pneumonia. The incidence of this infection in pregnancy has paralleled the increasing incidence of acquired immunodeficiency syndrome in pregnancy. Using the in vitro bidirectionally perfused human placenta, we studied the transfer of pentamidine across the placenta. Pentamidine was added to the maternal circulation at therapeutic concentrations (2 micrograms/ml). No transfer of pentamidine was detectable with a newly devised high-performance liquid chromatography method sensitive to 0.05 micrograms/ml of pentamidine. Increasing the pentamidine concentration tenfold produced a low level of transfer to the fetal circuit. Fetal concentrations were far below maternal perfusate concentrations. Placental tissue levels were higher than media levels. These data are suggestive of minimal drug transfer to the fetus and significant concentration of the drug in placental tissue. |
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Authors:
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S J Fortunato; R E Bawdon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 160 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1989 Mar |
Date Detail:
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Created Date: 1989-04-21 Completed Date: 1989-04-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 759-61 Citation Subset: AIM; IM; X |
Affiliation:
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Department of Obstetrics and Gynecology, East Tennessee State University, Johnson City 37614-0002. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amidines
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metabolism* Chromatography, High Pressure Liquid Female Humans Maternal-Fetal Exchange* Osmolar Concentration Pentamidine / metabolism* Perfusion Placenta / metabolism* Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Amidines; 100-33-4/Pentamidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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