Document Detail

Determination of paracetamol and orphenadrine citrate in pharmaceutical tablets by modeling of spectrophotometric data using partial least-squares and artificial neural networks.
MedLine Citation:
PMID:  17917430     Owner:  NLM     Status:  MEDLINE    
The estimation of paracetamol and orphenadrine citrate in a multicomponent pharmaceutical dosage form by spectrophotometric method has been reported. Because of highly interference in the spectra and the presence of non-linearity caused by the analyte concentrations which deviate from Beer and Lambert's law, partial least-squares (PLS) and artificial neural networks (ANN) techniques were used for the calibration. A validation set of spiked samples was employed for testing the accuracy and precision of the methods. Reasonably good recoveries were obtained with PLS for paracetamol and the use of an ANN allowed the estimation of orphenadrine citrate, a minor component which could not be adequately modeled by PLS. Three production batches of a commercial sample were analysed, and there was statistically no significant difference (P<0.05) between the results with the proposed method and those obtain with the official comparative method.
Lawan Sratthaphut; Nongluck Ruangwises
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan     Volume:  127     ISSN:  0031-6903     ISO Abbreviation:  Yakugaku Zasshi     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-05     Completed Date:  2008-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413613     Medline TA:  Yakugaku Zasshi     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1723-9     Citation Subset:  IM    
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayudhava Road, Rajathevee, Bangkok 10400, Thailand.
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MeSH Terms
Acetaminophen / analysis*
Analgesics / analysis*
Analgesics, Non-Narcotic / analysis*
Chemistry, Pharmaceutical / methods*
Neural Networks (Computer)*
Neuromuscular Agents / analysis*
Orphenadrine / chemistry*
Spectrophotometry / methods*
Tablets / chemistry*
Reg. No./Substance:
0/Analgesics; 0/Analgesics, Non-Narcotic; 0/Neuromuscular Agents; 0/Tablets; 103-90-2/Acetaminophen; 83-98-7/Orphenadrine

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