| Determination of para-aminobenzoic acid, a degradation product of procaine hydrochloride, by zero-crossing first-derivative spectrometry. | |
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MedLine Citation:
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PMID: 12207240 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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A first derivative spectrometric method has been developed for the determination of the para-aminobenzoic acid (PABA), a related substance and degradation product of the local anesthetic procaine hydrochloride (PH). The wavelength selected for the determination of para-aminobenzoic acid in the presence of procaine was 290 nm. At this wavelength the calibration graphs relating the amplitude of the signals to the concentration of para-aminobenzoic acid were linear up to 10 mg L(-1). The detection limit of para-aminobenzoic acid was 0.70 mg L(-1). The method is simple and rapid and does not require preliminary treatment of the sample. The method was validated. |
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Authors:
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Irinel Badea; Dana Moja; Luminita Vladescu |
Publication Detail:
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Type: Journal Article Date: 2002-07-31 |
Journal Detail:
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Title: Analytical and bioanalytical chemistry Volume: 374 ISSN: 1618-2642 ISO Abbreviation: Anal Bioanal Chem Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-09-03 Completed Date: 2002-11-26 Revised Date: 2003-11-03 |
Medline Journal Info:
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Nlm Unique ID: 101134327 Medline TA: Anal Bioanal Chem Country: Germany |
Other Details:
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Languages: eng Pagination: 51-3 Citation Subset: - |
Affiliation:
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Department of Analytical Chemistry, University of Bucharest, 2-14 Bv. Regina Elizabeta, Romania. irinel_badea@yahoo.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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