Document Detail

Determination of para-aminobenzoic acid, a degradation product of procaine hydrochloride, by zero-crossing first-derivative spectrometry.
MedLine Citation:
PMID:  12207240     Owner:  NLM     Status:  PubMed-not-MEDLINE    
A first derivative spectrometric method has been developed for the determination of the para-aminobenzoic acid (PABA), a related substance and degradation product of the local anesthetic procaine hydrochloride (PH). The wavelength selected for the determination of para-aminobenzoic acid in the presence of procaine was 290 nm. At this wavelength the calibration graphs relating the amplitude of the signals to the concentration of para-aminobenzoic acid were linear up to 10 mg L(-1). The detection limit of para-aminobenzoic acid was 0.70 mg L(-1). The method is simple and rapid and does not require preliminary treatment of the sample. The method was validated.
Irinel Badea; Dana Moja; Luminita Vladescu
Publication Detail:
Type:  Journal Article     Date:  2002-07-31
Journal Detail:
Title:  Analytical and bioanalytical chemistry     Volume:  374     ISSN:  1618-2642     ISO Abbreviation:  Anal Bioanal Chem     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-03     Completed Date:  2002-11-26     Revised Date:  2003-11-03    
Medline Journal Info:
Nlm Unique ID:  101134327     Medline TA:  Anal Bioanal Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  51-3     Citation Subset:  -    
Department of Analytical Chemistry, University of Bucharest, 2-14 Bv. Regina Elizabeta, Romania.
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