Document Detail


Determination of the origin of nondisjunction in a 49,XXXXY male using hypervariable dinucleotide repeat sequences.
MedLine Citation:
PMID:  2026425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present a patient with a 49,XXXXY chromosome constitution in whom the origin of the extra X chromosomes was determined by analysis of five polymorphic CA (or GT) dinucleotide repeat sequences. This class of DNA marker has recently been demonstrated to be hypervariable with heterozygosity values up to 80%. By polymerase chain reaction (PCR) analysis of the dinucleotide repeat length polymorphisms, we have shown that all four X chromosomes were of maternal origin.
Authors:
T H Huang; F Greenberg; D H Ledbetter
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human genetics     Volume:  86     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-06-10     Completed Date:  1991-06-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  619-20     Citation Subset:  IM    
Affiliation:
Institute for Molecular Genetics, Baylor College of Medicine, Houston, TX 77030.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple / genetics
Adolescent
Aneuploidy*
Heterozygote
Humans
Male
Nondisjunction, Genetic*
Polymerase Chain Reaction
Polymorphism, Genetic
Repetitive Sequences, Nucleic Acid*
X Chromosome*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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