Document Detail

Determination of optimal blood pressure for patients with IgA nephropathy based on renal histology.
MedLine Citation:
PMID:  11325079     Owner:  NLM     Status:  MEDLINE    
To evaluate the optimal BP control for patients with IgA nephropathy (IgAN) based on the histologic severity of the nephropathy and the degree of renal dysfunction. We analyzed 332 consecutive renal biopsy specimens and clinical data from patients with IgAN. Patients were divided into three groups based on their BP at the time of biopsy: an optimal BP (SBP<120 mmHg and DBP<80 mmHg), a hypertensive BP (SBP > or = 140 mmHg and/or DBP > or = 90 mmHg), and an intermediate BP group. Each biopsy specimen was evaluated for mesangial proliferation, degree of sclerosis and/or hyalinosis of the arterioles and the interlobular artery using a semiquantitative method. Creatinine clearance and the percentage of sclerosed glomeruli were also determined. Both the degree of renal dysfunction and the histologic changes correlated significantly with BP, even in patients with a BP <140/90 mmHg. The patients with an optimal BP at the time of biopsy had significantly less histologic damage with respect to mesangial proliferation and vessel changes than those with an intermediate or hypertensive BP. In the patients with a hypertensive BP, the percentage of sclerotic glomeruli was significantly higher and the creatinine clearance was significantly lower. The optimal BP proposed by the WHO in 1999 prevents histologic evidence of renal damage for patients with IgAN.
Y Osawa; I Narita; N Imai; N Iino; S Iguchi; M Ueno; H Shimada; S Nishi; M Arakawa; F Gejyo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  24     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-04-27     Completed Date:  2001-08-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  89-92     Citation Subset:  IM    
Department of Medicine, Niigata University School of Medicine, Japan.
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MeSH Terms
Blood Pressure*
Glomerular Mesangium / pathology
Glomerulonephritis, IGA / pathology*,  physiopathology*
Hypertension, Renal / pathology*,  physiopathology*
Middle Aged
Predictive Value of Tests

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