| Determination of a novel bile acid sequestrant in rodent diet by near-infrared spectroscopy. | |
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MedLine Citation:
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PMID: 10698556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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DMP 504 is a high molecular weight polymer currently under development by The DuPont Merck Pharmaceutical Company as a novel bile acid sequestrant to lower serum cholesterol. To assess its safety, DMP 504 is incorporated into rodent diet for oral administration to rats and mice. An analytical method was developed to determine the accuracy and homogeneity of the blends. Since a physical separation or extraction of DMP 504 from the diet was not feasible, near-infrared spectroscopy (near-IR) was employed. The near-IR method provides accurate and precise results for blends containing 1.5-8.0% of DMP 504. Comparison of results at the 1.5% level with a cholate binding referee method is also presented. Both methods provided equivalent results for the 1.5% level. |
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Authors:
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J R Scull; K L Moyer; J S Green; R W Woodeshick; M S Alasandro |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical and biomedical analysis Volume: 19 ISSN: 0731-7085 ISO Abbreviation: J Pharm Biomed Anal Publication Date: 1999 May |
Date Detail:
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Created Date: 2000-03-21 Completed Date: 2000-03-21 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8309336 Medline TA: J Pharm Biomed Anal Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 903-10 Citation Subset: IM |
Affiliation:
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DuPont Merck Pharmaceuticals Company, Analytical R&D, Wilmington, DE 19880, USA. james.r.scull@dupontpharma.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile Acids and Salts / metabolism Calibration Diet* Polymers / analysis* Quality Control Quaternary Ammonium Compounds / analysis* Reproducibility of Results Rodentia Spectroscopy, Near-Infrared / methods* |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/DMP-504; 0/Polymers; 0/Quaternary Ammonium Compounds |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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