Document Detail


Determination of a new cerebral vasodilator 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]-ethyl ester 5-methyl ester hydrochloride (YC-93) in plasma by electron capture gas chromatography.
MedLine Citation:
PMID:  1150838     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A highly sensitive method for the quantitative determination of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]-ethyl ester 5-methyl ester hydrochloride (YC-93) in plasma is described. After extraction, YC-93 was oxidized to a pyridine analogue with nitrous acid and detected by electron capture gas chromatography. The sensitivity was 2-3 ng/ml, which is sufficient to determine plasma concentrations of YC-93 after oral administration of clinical doses to humans.
Authors:
S Higuchi; H Sasaki; T Sado
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of chromatography     Volume:  110     ISSN:  -     ISO Abbreviation:  J. Chromatogr.     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-11-05     Completed Date:  1975-11-05     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0427043     Medline TA:  J Chromatogr     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  301-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chromatography, Gas
Dicarboxylic Acids / blood
Humans
Methods
Nitrobenzenes / blood
Oxidation-Reduction
Pyridines / blood*
Vasodilator Agents / blood*
Chemical
Reg. No./Substance:
0/Dicarboxylic Acids; 0/Nitrobenzenes; 0/Pyridines; 0/Vasodilator Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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