| Determination of a new cerebral vasodilator 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]-ethyl ester 5-methyl ester hydrochloride (YC-93) in plasma by electron capture gas chromatography. | |
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MedLine Citation:
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PMID: 1150838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A highly sensitive method for the quantitative determination of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]-ethyl ester 5-methyl ester hydrochloride (YC-93) in plasma is described. After extraction, YC-93 was oxidized to a pyridine analogue with nitrous acid and detected by electron capture gas chromatography. The sensitivity was 2-3 ng/ml, which is sufficient to determine plasma concentrations of YC-93 after oral administration of clinical doses to humans. |
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Authors:
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S Higuchi; H Sasaki; T Sado |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of chromatography Volume: 110 ISSN: 0021-9673 ISO Abbreviation: J. Chromatogr. Publication Date: 1975 Jul |
Date Detail:
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Created Date: 1975-11-05 Completed Date: 1975-11-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0427043 Medline TA: J Chromatogr Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 301-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, Gas Dicarboxylic Acids / blood Humans Methods Nitrobenzenes / blood Oxidation-Reduction Pyridines / blood* Vasodilator Agents / blood* |
| Chemical | |
Reg. No./Substance:
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0/Dicarboxylic Acids; 0/Nitrobenzenes; 0/Pyridines; 0/Vasodilator Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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