Document Detail

Determination of n-octanol-water partition coefficients by hollow-fiber membrane solvent microextraction coupled with HPLC.
MedLine Citation:
PMID:  17082876     Owner:  NLM     Status:  MEDLINE    
A novel direct method has been developed for determination of n-octanol-water partition coefficients by hollow-fiber membrane solvent microextraction (HFMSME) combined with high-performance liquid chromatography (HPLC). The compound of interest is dissolved in water with sonication and a hollow fiber containing octanol inside is placed in the sample solution to perform microextraction. After microextraction the concentrations in both the aqueous and n-octanol phases are analyzed by HPLC with UV detection. The method was evaluated with ten reference compounds and shown to be suitable for determination of the partition coefficients of organic compounds accurately, cheaply, simply, and quickly. Previously unknown n-octanol-water partition coefficients have been obtained for other compounds by use of the hollow-fiber membrane solvent-microextraction technique.
Yu Gao Guo; Jie Zhang; Dan Ning Liu; Hua Feng Fu
Related Documents :
12885056 - Solid-phase microextraction for herbicide determination in environmental samples.
19787516 - Analytical approaches to identify potential migrants in polyester-polyurethane can coat...
21344206 - Construction of an effective screening system for detection of pseudomonas aeruginosa q...
18836706 - Recent developments in solid-phase microextraction.
24062966 - Validation and application of a new reversed phase hplc method for in vitro dissolution...
6869546 - Differential transit of liquids and solid residue through the human ileum.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-03
Journal Detail:
Title:  Analytical and bioanalytical chemistry     Volume:  386     ISSN:  1618-2642     ISO Abbreviation:  Anal Bioanal Chem     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-20     Completed Date:  2007-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134327     Medline TA:  Anal Bioanal Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2193-8     Citation Subset:  IM    
College of Pharmaceutical Sciences and Biotechnology, Tianjin University, Tianjin 300072, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
1-Octanol / chemistry*
Aniline Compounds / chemistry
Chromatography, High Pressure Liquid / methods*
Water / chemistry*
Reg. No./Substance:
0/Aniline Compounds; 0/Solvents; 111-87-5/1-Octanol; 62-53-3/aniline; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Simultaneous determination of uric acid and ascorbic acid at a ferrocenium-thioglycollate modified e...
Next Document:  Quantitative determination of ginsenoside Rh2 in rat biosamples by liquid chromatography electrospra...