Document Detail

Determination of mycotoxins in foods: current state of analytical methods and limitations.
MedLine Citation:
PMID:  20339844     Owner:  NLM     Status:  MEDLINE    
Mycotoxins are natural contaminants produced by a range of fungal species. Their common occurrence in food and feed poses a threat to the health of humans and animals. This threat is caused either by the direct contamination of agricultural commodities or by a "carry-over" of mycotoxins and their metabolites into animal tissues, milk, and eggs after feeding of contaminated hay or corn. As a consequence of their diverse chemical structures and varying physical properties, mycotoxins exhibit a wide range of biological effects. Individual mycotoxins can be genotoxic, mutagenic, carcinogenic, teratogenic, and oestrogenic. To protect consumer health and to reduce economic losses, surveillance and control of mycotoxins in food and feed has become a major objective for producers, regulatory authorities and researchers worldwide. However, the variety of chemical structures makes it impossible to use one single technique for mycotoxin analysis. Hence, a vast number of analytical methods has been developed and validated. The heterogeneity of food matrices combined with the demand for a fast, simultaneous and accurate determination of multiple mycotoxins creates enormous challenges for routine analysis. The most crucial issues will be discussed in this review. These are (1) the collection of representative samples, (2) the performance of classical and emerging analytical methods based on chromatographic or immunochemical techniques, (3) the validation of official methods for enforcement, and (4) the limitations and future prospects of the current methods.
Robert Köppen; Matthias Koch; David Siegel; Stefan Merkel; Ronald Maul; Irene Nehls
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-03-26
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  86     ISSN:  1432-0614     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-22     Completed Date:  2010-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1595-612     Citation Subset:  IM    
BAM Federal Institute for Material Research and Testing, Richard-Willstätter-Str. 11, 12489, Berlin, Germany.
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MeSH Terms
Chromatography, Gas / standards
Chromatography, High Pressure Liquid / standards
Food Contamination*
Food Handling
Food Microbiology*
Fungi / growth & development,  metabolism
Immunoassay / standards
Mass Spectrometry / standards
Mycotoxins / analysis*,  chemistry,  metabolism,  toxicity
Reproducibility of Results
Reg. No./Substance:

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