Document Detail


Determination of metabolites of xenobiotics in the bile of fish from polluted waterways.
MedLine Citation:
PMID:  6495757     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An h.p.l.c.-fluorescence technique was used to estimate relative concentrations of metabolites of xenobiotics in bile of 103 English sole (Parophrys vetulus) from both polluted and minimally polluted (reference) sites in Puget Sound, WA. Fish from polluted sites had concentrations of xenobiotics in bile with naphthalene-, phenanthrene- and benzo[a]pyrene-like fluorescence that averaged 9, 14 and 19 times, respectively, those of fish from reference sites. Within a polluted site, fish with liver lesions had significantly higher bile concentrations of xenobiotics with benzo[a]pyrene-like fluorescence than did fish without liver lesions. Individual metabolites of fluorene, phenanthrene, anthracene, biphenyl and dimethylnaphthalene were determined by g.l.c.-mass spectrometry in extracts of hydrolysed bile of three English sole from polluted waterways; concentrations ranged from 90 to 19000 ng/g, wet wt. Other xenobiotics were tentatively identified, but not quantified.
Authors:
M M Krahn; M S Myers; D G Burrows; D C Malins
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Xenobiotica; the fate of foreign compounds in biological systems     Volume:  14     ISSN:  0049-8254     ISO Abbreviation:  Xenobiotica     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-12-11     Completed Date:  1984-12-11     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  1306665     Medline TA:  Xenobiotica     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  633-46     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzo(a)pyrene / metabolism
Bile / metabolism*
Chromatography, High Pressure Liquid
Drug-Induced Liver Injury
Fish Diseases / chemically induced
Fishes / metabolism*
Hydrocarbons / metabolism*
Liver Diseases / pathology,  veterinary
Naphthalenes / metabolism
Phenanthrenes / metabolism
Spectrometry, Fluorescence
Water Pollutants* / toxicity
Water Pollutants, Chemical* / toxicity
Chemical
Reg. No./Substance:
0/Hydrocarbons; 0/Naphthalenes; 0/Phenanthrenes; 0/Water Pollutants; 0/Water Pollutants, Chemical; 50-32-8/Benzo(a)pyrene; 85-01-8/phenanthrene; 91-20-3/naphthalene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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