Document Detail

Determination of mass transfer dissolution rate constants from critical time of dissolution of a powder sample.
MedLine Citation:
PMID:  10027207     Owner:  NLM     Status:  MEDLINE    
This article presents a method for obtaining mass transfer dissolution rate constants of polydisperse, particulate solids under given hydrodynamic conditions. Oxalic acid, salicylic acid, and phthalimide were recrystallized and classified into various mesh cuts, which were then subjected to dissolution in a USP dissolution apparatus II. Expressions were derived for the anticipated dissolution profiles, and it is shown that cube root plots should show a nick at the point were the smallest particle dissolves. Time and microscopic dimensions then allow calculation of the mass transfer dissolution rate constant.
J T Carstensen; M Dali
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmaceutical development and technology     Volume:  4     ISSN:  1083-7450     ISO Abbreviation:  Pharm Dev Technol     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-05-17     Completed Date:  1999-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9610932     Medline TA:  Pharm Dev Technol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Bristol-Myers-Squibb, New Brunswick, New Jersey, USA.
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MeSH Terms
Chemistry, Pharmaceutical
Oxalic Acid / chemistry
Particle Size
Phthalimides / chemistry
Powders / chemistry*
Salicylic Acid / chemistry
Time Factors
Reg. No./Substance:
0/Phthalimides; 0/Powders; 144-62-7/Oxalic Acid; 69-72-7/Salicylic Acid; 85-41-6/phthalimide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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