Document Detail


Determination of mass transfer dissolution rate constants from critical time of dissolution of a powder sample.
MedLine Citation:
PMID:  10027207     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This article presents a method for obtaining mass transfer dissolution rate constants of polydisperse, particulate solids under given hydrodynamic conditions. Oxalic acid, salicylic acid, and phthalimide were recrystallized and classified into various mesh cuts, which were then subjected to dissolution in a USP dissolution apparatus II. Expressions were derived for the anticipated dissolution profiles, and it is shown that cube root plots should show a nick at the point were the smallest particle dissolves. Time and microscopic dimensions then allow calculation of the mass transfer dissolution rate constant.
Authors:
J T Carstensen; M Dali
Related Documents :
3044647 - Determination of cholic acid and chenodeoxycholic acid pool sizes and fractional turnov...
6839487 - 125i radioimmunoassay of serum ursodeoxycholyl conjugates.
9737577 - Bile acids influence hepatic chemiluminescence in normal and oxidative-stressed rats.
7615207 - Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithochola...
19093527 - Study on lipid changes of leaves and fruits olive adapted to high temperature condition...
19491837 - Does the presence of a hiatal hernia affect the efficacy of the reflux inhibitor baclof...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmaceutical development and technology     Volume:  4     ISSN:  1083-7450     ISO Abbreviation:  Pharm Dev Technol     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-05-17     Completed Date:  1999-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9610932     Medline TA:  Pharm Dev Technol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Affiliation:
Bristol-Myers-Squibb, New Brunswick, New Jersey, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Chemistry, Pharmaceutical
Crystallization
Kinetics
Oxalic Acid / chemistry
Particle Size
Phthalimides / chemistry
Powders / chemistry*
Salicylic Acid / chemistry
Solubility
Time Factors
Chemical
Reg. No./Substance:
0/Phthalimides; 0/Powders; 144-62-7/Oxalic Acid; 69-72-7/Salicylic Acid; 85-41-6/phthalimide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Treatment of estrogen deficiency symptoms in women surviving breast cancer. Part 1: Defining the pro...
Next Document:  Dissolution of ibuprofen enantiomers from coprecipitates and suspensions containing chiral excipient...