| Determination of limb bud chondrocytes during a transient block of the cell cycle. | |
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MedLine Citation:
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PMID: 167985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The process of determination is studied by using a cell culture system derived from dissociated chick embryo limb buds. When limb bud cells obtained from embryos younger than stage 25 (undertermined) are temporarily prevented from passing through the cell cycle (either by maintaining the cells on a petri dish or in the presence of high concentrations of cyclic AMP, both of which depress thymidine-H(3) incorporation), some cells subsequently form cartilage colonies. These results support the hypothesis that a temporary block at some stage in the cell cycle causes mesoblasts to acquire the capacity to differentiate into cartilage cells. |
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Authors:
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M Solursh; R S Reiter |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cell differentiation Volume: 4 ISSN: 0045-6039 ISO Abbreviation: Cell Differ. Publication Date: 1975 Jun |
Date Detail:
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Created Date: 1975-11-05 Completed Date: 1975-11-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0342640 Medline TA: Cell Differ Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 131-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminopterin
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pharmacology Animals Bucladesine / pharmacology Cartilage / cytology, embryology* Cell Adhesion Cell Differentiation* / drug effects Cell Division Cells, Cultured Chick Embryo Colchicine / pharmacology Cytarabine / pharmacology DNA / biosynthesis Extremities / cytology, embryology* Floxuridine / pharmacology Hydroxyurea / pharmacology Theophylline / pharmacology Thymidine / pharmacology |
| Chemical | |
Reg. No./Substance:
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127-07-1/Hydroxyurea; 147-94-4/Cytarabine; 362-74-3/Bucladesine; 50-89-5/Thymidine; 50-91-9/Floxuridine; 54-62-6/Aminopterin; 58-55-9/Theophylline; 64-86-8/Colchicine; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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