Document Detail

Determination of limb bud chondrocytes during a transient block of the cell cycle.
MedLine Citation:
PMID:  167985     Owner:  NLM     Status:  MEDLINE    
The process of determination is studied by using a cell culture system derived from dissociated chick embryo limb buds. When limb bud cells obtained from embryos younger than stage 25 (undertermined) are temporarily prevented from passing through the cell cycle (either by maintaining the cells on a petri dish or in the presence of high concentrations of cyclic AMP, both of which depress thymidine-H(3) incorporation), some cells subsequently form cartilage colonies. These results support the hypothesis that a temporary block at some stage in the cell cycle causes mesoblasts to acquire the capacity to differentiate into cartilage cells.
M Solursh; R S Reiter
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell differentiation     Volume:  4     ISSN:  0045-6039     ISO Abbreviation:  Cell Differ.     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-11-05     Completed Date:  1975-11-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0342640     Medline TA:  Cell Differ     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  131-7     Citation Subset:  IM    
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MeSH Terms
Aminopterin / pharmacology
Bucladesine / pharmacology
Cartilage / cytology,  embryology*
Cell Adhesion
Cell Differentiation* / drug effects
Cell Division
Cells, Cultured
Chick Embryo
Colchicine / pharmacology
Cytarabine / pharmacology
DNA / biosynthesis
Extremities / cytology,  embryology*
Floxuridine / pharmacology
Hydroxyurea / pharmacology
Theophylline / pharmacology
Thymidine / pharmacology
Reg. No./Substance:
127-07-1/Hydroxyurea; 147-94-4/Cytarabine; 362-74-3/Bucladesine; 50-89-5/Thymidine; 50-91-9/Floxuridine; 54-62-6/Aminopterin; 58-55-9/Theophylline; 64-86-8/Colchicine; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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