Document Detail


Determination of the layer-specific distributed collagen fibre orientations in human thoracic and abdominal aortas and common iliac arteries.
MedLine Citation:
PMID:  22171063     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The established method of polarized microscopy in combination with a universal stage is used to determine the layer-specific distributed collagen fibre orientations in 11 human non-atherosclerotic thoracic and abdominal aortas and common iliac arteries (63 ± 15.3 years, mean ± s.d.). A dispersion model is used to quantify over 37 000 recorded fibre angles from tissue samples. The study resulted in distinct fibre families, fibre directions, dispersion and thickness data for each layer and all vessels investigated. Two fibre families were present for the intima, media and adventitia in the aortas, with often a third and sometimes a fourth family in the intima in the respective axial and circumferential directions. In all aortas, the two families were almost symmetrically arranged with respect to the cylinder axis, closer to the axial direction in the adventitia, closer to the circumferential direction in the media and in between in the intima. The same trend was found for the intima and adventitia of the common iliac arteries; however, there was only one preferred fibre alignment present in the media. In all locations and layers, the observed fibre orientations were always in the tangential plane of the walls, with no radial components and very small dispersion through the wall thickness. A wider range of in-plane fibre orientations was present in the intima than in the media and adventitia. The mean total wall thickness for the aortas and the common iliac artery was 1.39 and 1.05 mm, respectively. For the aortas, a slight thickening of the intima and a thinning of the media in increasingly distal regions were observed. A clear intimal thickening was present distal to the branching of the celiac arteries. All data, except for the media of the common iliac arteries, showed two prominent collagen fibre families for all layers so that two-fibre family models seem most appropriate.
Authors:
Andreas J Schriefl; Georg Zeindlinger; David M Pierce; Peter Regitnig; Gerhard A Holzapfel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-12-14
Journal Detail:
Title:  Journal of the Royal Society, Interface / the Royal Society     Volume:  9     ISSN:  1742-5662     ISO Abbreviation:  J R Soc Interface     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-08-15     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101217269     Medline TA:  J R Soc Interface     Country:  England    
Other Details:
Languages:  eng     Pagination:  1275-86     Citation Subset:  IM    
Affiliation:
Institute of Biomechanics, Center of Biomedical Engineering, Graz University of Technology, Kronesgasse 5-I, 8010 Graz, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aorta, Abdominal / chemistry*,  ultrastructure*
Computer Simulation
Female
Humans
Iliac Artery / chemistry*,  ultrastructure*
Male
Middle Aged
Models, Anatomic*
Models, Cardiovascular
Models, Chemical
Molecular Conformation
Thoracic Arteries / chemistry*,  ultrastructure*
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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