Document Detail


Determination of isamoxole (N-butyl-N-(4-methyloxazol-2-yl)-2-methylpropanamide, LRCL 3950) in plasma by selected ion monitoring using a stable isotope internal standard.
MedLine Citation:
PMID:  678619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A selected ion monitoring method for the estimation of an anti-allergy compound isamaxole (N-butyl-N-(4-methyloxazol-2-yl)-2-methylpropanamide, LRCL 3950) in plasma has been developed. The method uses a stable analogue containing nine deuterium atoms as internal standard. The assay is sensitive to 2 ng ml-1 plasma and has been used to examine plasma levels of isamoxole after doses of the compound to animals and man.
Authors:
D H Chatfield; T J Woodage
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedical mass spectrometry     Volume:  5     ISSN:  0306-042X     ISO Abbreviation:  Biomed. Mass Spectrom.     Publication Date:  1978 Jul 
Date Detail:
Created Date:  1978-10-27     Completed Date:  1978-10-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0430246     Medline TA:  Biomed Mass Spectrom     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  466-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Intestinal Absorption
Male
Mass Spectrometry / methods*
Oxazoles / blood*
Rats
Chemical
Reg. No./Substance:
0/Oxazoles

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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