Document Detail

Determination of the in vivo prebiotic potential of a maize-based whole grain breakfast cereal: a human feeding study.
MedLine Citation:
PMID:  20487589     Owner:  NLM     Status:  MEDLINE    
Epidemiological studies have shown an inverse relationship between risk of CVD and intake of whole grain (WG)-rich food. Regular consumption of breakfast cereals can provide not only an increase in dietary WG but also improvements to cardiovascular health. Various mechanisms have been proposed, including prebiotic modulation of the colonic microbiota. In the present study, the prebiotic activity of a maize-derived WG cereal (WGM) was evaluated in a double-blind, placebo-controlled human feeding study (n 32). For a period of 21 d, healthy men and women, mean age 32 (sd 8) years and BMI 23·3 (sd 0·58) kg/m2, consumed either 48 g/d WG cereal (WGM) or 48 g placebo cereal (non-whole grain (NWG)) in a crossover fashion. Faecal samples were collected at five points during the study on days 0, 21, 42, 63 and 84 (representing at baseline, after both treatments and both wash-out periods). Faecal bacteriology was assessed using fluorescence in situ hybridisation with 16S rRNA oligonucleotide probes specific for Bacteroides spp., Bifidobacterium spp., Clostridium histolyticum/perfringens subgroup, Lactobacillus-Enterococcus subgroup and total bacteria. After 21 d consumption of WGM, mean group levels of faecal bifidobacteria increased significantly compared with the control cereal (P = 0·001). After a 3-week wash-out period, bifidobacterial levels returned to pre-intervention levels. No statistically significant changes were observed in serum lipids, glucose or measures of faecal output. In conclusion, this WG maize-enriched breakfast cereal mediated a bifidogenic modulation of the gut microbiota, indicating a possible prebiotic mode of action.
Andrew L Carvalho-Wells; Kathrin Helmolz; Cecelia Nodet; Christine Molzer; Clare Leonard; Brigid McKevith; Frank Thielecke; Kim G Jackson; Kieran M Tuohy
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-05-21
Journal Detail:
Title:  The British journal of nutrition     Volume:  104     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2010-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1353-6     Citation Subset:  IM    
Nutrition Research Group, Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AP, UK.
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MeSH Terms
Bacterial Typing Techniques / methods
Bifidobacterium / genetics,  growth & development*
Colon / microbiology*
Cross-Over Studies
Double-Blind Method
Feces / microbiology
Food Handling
Middle Aged
Plant Preparations / pharmacology*
RNA, Ribosomal, 16S
Young Adult
Zea mays*
Reg. No./Substance:
0/Plant Preparations; 0/Prebiotics; 0/RNA, Ribosomal, 16S

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