Document Detail

Determination of hexavalent chromium in cosmetic products by ion chromatography and postcolumn derivatization.
MedLine Citation:
PMID:  16689807     Owner:  NLM     Status:  MEDLINE    
Chromium hydroxide green [Cr(2)O(OH)(4)] and chromium oxide green (Cr(2)O(3)) are colouring agents for use in cosmetic products. These colourants may contain chromium (VI), which cause skin allergies through percutaneous adsorption on the skin. Eye shadow is a representative cosmetic product in which significant colourants are used. We analysed the chromium (VI) in the eye shadows by ion chromatography and post column derivatization. We optimize conditions of chromium (VI) analysis in eye shadows. During the pretreatment procedure, there are no exchange of chromium (III) to chromium (VI). This method has a limit of quantification for chromium (VI) of 1.0 microg l(-1), recovery rate of 100 +/- 3% and analysis time less than 10 min. This result is 300 times more sensitive than the high-performance liquid chromatography method. We applied the optimized method to analyse 22 eye shadows and 6 colouring agents. 2 out of 22 of the products contained more than 5 mg l(-1). In our previous work, 5 mg l(-1) of Cr represented a threshold level. There was much more Cr(VI) in the colouring agents. The Cr(VI) in one of the colouring agents was 97.6 mg l(-1).
Eun Kyung Kang; Somi Lee; Jin-Hee Park; Kyung-Mi Joo; Hye-Jin Jeong; Ih Seop Chang
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Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  Contact dermatitis     Volume:  54     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-12     Completed Date:  2006-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  244-8     Citation Subset:  IM    
Skin Research Institute, Amorepacific Corporation R&D Center, Yongin 449-729, Korea.
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MeSH Terms
Allergens / adverse effects*,  chemistry
Chromatography, High Pressure Liquid
Chromium / adverse effects*,  chemistry
Cosmetics / adverse effects*,  chemistry
Dermatitis, Allergic Contact / etiology*
Reproducibility of Results
Reg. No./Substance:
0/Allergens; 0/Cosmetics; 18540-29-9/chromium hexavalent ion; 7440-47-3/Chromium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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