Document Detail


Determination of haemoglobin adducts of acrylamide and glycidamide in smoking and non-smoking persons of the general population.
MedLine Citation:
PMID:  15729833     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acrylamide (AA) is a food-borne toxicant suspected to be carcinogenic to humans. It is formed in the heating process of starch-containing food. Currently, there is a great discussion about the possible human health risks connected with the dietary uptake of acrylamide. Haemoglobin adducts of acrylamide and its oxidative metabolite glycidamide are both markers of biochemical effect. However, because glycidamide has a higher carcinogenic potency than acrylamide itself, the glycidamide adduct might mirror the genotoxicity better than acrylamide adducts. In order to gain more information about the human metabolism of acrylamide, we investigated a small group of persons for the effective internal doses of acrylamide and glycidamide using haemoglobin adducts as parameters of biochemical effect. The collective was subdivided into non-smokers (n=13) and smokers (n=16) by determining the smoking-specific acrylonitrile haemoglobin adduct (N-cyanoethylvaline, CEV). The mean values for the adducts of acrylamide (N-2-carbamoylethylvaline, AAVal) and glycidamide (N-(R,S)-2-hydroxy-2-carbamoylethylvaline, GAVal) in nonsmokers was 19 pmol/g globin AAVal (range 7-31 pmol/g globin) and 17 pmol/g globin GAVal (range 9-23 pmol/g globin). For smokers mean levels of AAVal were 80 pmol/g globin (range: 25-199 pmol/g globin) and those of GAVal were 53 pmol/g globin (range: 22-119 pmol/g globin). Metabolism to glycidamide turned out to be significantly more effective in non-smokers than in the higher exposed smokers. Compared with studies in rats, the metabolic conversion of acrylamide to glycidamide as measured by haemoglobin adducts seems to occur to a similar extent in humans as in rats. Risk estimations on acrylamide based on experimental data obtained in rats obviously did not overestimate the cancer risk for the general population. Furthermore, our results might indicate that the dose-response curve for acrylamide is not linear. This would be in line with the results of animal experiments on rodents.
Authors:
Thomas Schettgen; Bernd Rossbach; Birgitta Kütting; Stefan Letzel; Hans Drexler; Jürgen Angerer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of hygiene and environmental health     Volume:  207     ISSN:  1438-4639     ISO Abbreviation:  Int J Hyg Environ Health     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-02-25     Completed Date:  2005-12-15     Revised Date:  2007-06-21    
Medline Journal Info:
Nlm Unique ID:  100898843     Medline TA:  Int J Hyg Environ Health     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  531-9     Citation Subset:  IM    
Affiliation:
Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander-University of Erlangen-Nuremberg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Acrylamide / administration & dosage,  metabolism*
Acrylamides / blood,  metabolism*
Adolescent
Adult
Aged
Biological Markers / blood
Epoxy Compounds / administration & dosage,  metabolism*
Female
Gas Chromatography-Mass Spectrometry
Germany
Hemoglobins / chemistry,  metabolism*
Humans
Male
Middle Aged
Protein Binding
Smoking / blood,  metabolism*
Valine / analogs & derivatives*,  blood,  metabolism
Chemical
Reg. No./Substance:
0/Acrylamides; 0/Biological Markers; 0/Epoxy Compounds; 0/Hemoglobins; 0/N-(2-carbamoyethyl)valine; 0/N-(RS)-2-hydroxy-2-carbamoylethylvaline; 5694-00-8/glycidamide; 7004-03-7/Valine; 79-06-1/Acrylamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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