| Determination of furosemide in plasma and urine by gas chromatography/mass spectrometry. | |
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MedLine Citation:
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PMID: 8901149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new method for the determination of furosemide (CAS 54-31-9) in plasma and urine by gas chromatography/mass spectrometry (GC/MS) has been developed. After acidification the samples were extracted by ethyl acetate and methylated by methyl iodide. The chromatography was carried out on a fused-silica capillary column with SE-54 stationary phase. Detection was performed by selected ion monitoring (ions 81 and 372 were monitored for furosemide and ions 363 and 406 for internal standard bumetanide). Limit of quantitation was 10 ng/ml for plasma and 40 ng/ml for urine and the calibration curves were linear up to 100,000 ng/ml. |
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Authors:
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P Ptácek; O Vyhnálek; H P Breuel; J Macek |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 46 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1997-01-13 Completed Date: 1997-01-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY |
Other Details:
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Languages: eng Pagination: 277-83 Citation Subset: IM |
Affiliation:
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Tranquillitas Laboratories, Prague, Czech Republic. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bumetanide
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chemistry Calibration Diuretics / analysis*, pharmacokinetics Furosemide / analysis*, pharmacokinetics Gas Chromatography-Mass Spectrometry Half-Life Humans Kidney Diseases / blood, urine Quality Control |
| Chemical | |
Reg. No./Substance:
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0/Diuretics; 28395-03-1/Bumetanide; 54-31-9/Furosemide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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