Document Detail

Determination of free amino acid content in Radix Pseudostellariae using near infrared (NIR) spectroscopy and different multivariate calibrations.
MedLine Citation:
PMID:  19616914     Owner:  NLM     Status:  MEDLINE    
Near infrared (NIR) spectroscopy combined with multivariate calibration was attempted to analyze free amino acid content of Radix Pseudostellariae. The original spectra of Pseudostellariae samples in wavelength range of 10000-4000 cm(-1) were acquired. Partial least squares (PLS), kernel PLS (k-PLS), back propagation neural network (BP-NN), and support vector regression (SVR) algorithms were performed comparatively to develop calibration models. Some parameters of the calibration models were optimized by cross-validation. The performance of BP-NN model was better than PLS, k-PLS, and SVR models. The root mean square error of prediction (RMSEP) and the correlation coefficient (R) of BP-NN model were 0.687 and 0.889 in prediction set respectively. Results showed that NIR spectroscopy combined with multivariate calibration has significant potential in quantitative analysis of free amino acid content in Radix Pseudostellariae.
Hao Lin; Quansheng Chen; Jiewen Zhao; Ping Zhou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-27
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  50     ISSN:  1873-264X     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-09-25     Completed Date:  2010-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  England    
Other Details:
Languages:  eng     Pagination:  803-8     Citation Subset:  IM    
School of Food & Biological Engineering, Jiangsu University, Xuefu Road 301#, Jiangsu, 212013 Zhenjiang, PR China.
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MeSH Terms
Amino Acids / analysis*,  chemistry
Chemistry, Pharmaceutical / methods*
Least-Squares Analysis
Medicine, Chinese Traditional
Models, Statistical
Multivariate Analysis
Plant Extracts / metabolism*
Ranunculaceae / metabolism*
Regression Analysis
Reproducibility of Results
Spectroscopy, Near-Infrared / methods*
Time Factors
Reg. No./Substance:
0/Amino Acids; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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